Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 3973525..3974189 Replicon chromosome
Accession NZ_CP024996
Organism Herbaspirillum rubrisubalbicans strain DSM 11543

Toxin (Protein)


Gene name higB Uniprot ID A0A0U3LID1
Locus tag RC54_RS17640 Protein ID WP_058896304.1
Coordinates 3973845..3974189 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0U3K789
Locus tag RC54_RS17635 Protein ID WP_044531392.1
Coordinates 3973525..3973848 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RC54_RS17610 3969402..3970142 + 741 WP_058896301.1 hypothetical protein -
RC54_RS17615 3970501..3970698 - 198 WP_058896302.1 hypothetical protein -
RC54_RS17620 3970698..3970928 - 231 WP_017452985.1 hypothetical protein -
RC54_RS17625 3971080..3972471 - 1392 WP_017452986.1 ABC transporter substrate-binding protein -
RC54_RS17630 3972612..3973331 - 720 WP_058896303.1 FadR family transcriptional regulator -
RC54_RS17635 3973525..3973848 - 324 WP_044531392.1 XRE family transcriptional regulator Antitoxin
RC54_RS17640 3973845..3974189 - 345 WP_058896304.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RC54_RS17645 3974294..3975199 + 906 WP_061790548.1 LysR family transcriptional regulator -
RC54_RS17650 3975338..3976171 + 834 WP_058896306.1 putative hydro-lyase -
RC54_RS17655 3976283..3977527 + 1245 WP_044531396.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13595.67 Da        Isoelectric Point: 9.8225

>T89424 WP_058896304.1 NZ_CP024996:c3974189-3973845 [Herbaspirillum rubrisubalbicans]
MEAVFKETRMFEAYRANYLSDEAYAELQQMLMRHPHAGKLIKDTGGLRKIRFPDARRCKGKRGGLRVIYYFWSEERQFWL
FSIYDKNEMADLTAEQRKLLKHVLEDELARGKTS

Download         Length: 345 bp

>T89424 NZ_CP024996:c3974189-3973845 [Herbaspirillum rubrisubalbicans]
ATGGAAGCCGTATTCAAAGAAACGCGAATGTTTGAAGCCTACCGGGCGAACTATCTCTCGGATGAGGCATATGCTGAACT
TCAACAGATGTTGATGAGGCATCCTCATGCGGGCAAGCTGATCAAGGATACGGGTGGACTAAGGAAGATTCGTTTTCCTG
ATGCACGCCGTTGCAAGGGTAAACGCGGGGGCTTGCGGGTCATCTATTATTTTTGGAGTGAAGAACGTCAGTTCTGGCTT
TTTTCAATCTATGACAAAAATGAAATGGCTGACCTGACAGCCGAACAGCGCAAGCTGCTCAAACACGTTCTTGAAGATGA
ATTGGCCCGAGGGAAAACATCATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12032.07 Da        Isoelectric Point: 11.2202

>AT89424 WP_044531392.1 NZ_CP024996:c3973848-3973525 [Herbaspirillum rubrisubalbicans]
MKKKRNLFDELMAGVEDMAAERKGKLTLRTTKVKLSPEPVSITAEEIQRVRSKVRVSQAIMARSLRVNARTYQNWEQGVS
RPNAQAAVLLKLVDQDPSLIARISSLV

Download         Length: 324 bp

>AT89424 NZ_CP024996:c3973848-3973525 [Herbaspirillum rubrisubalbicans]
ATGAAGAAGAAAAGAAACCTGTTCGACGAACTGATGGCCGGAGTCGAGGACATGGCCGCCGAGCGCAAAGGTAAGCTCAC
TTTACGCACTACCAAGGTGAAGCTATCGCCGGAACCTGTCTCGATTACTGCCGAAGAGATTCAGCGAGTCAGGAGCAAGG
TACGTGTTTCGCAAGCCATCATGGCGCGCAGTCTGCGCGTCAATGCCCGCACCTATCAGAACTGGGAACAGGGCGTCTCC
CGTCCGAATGCCCAGGCTGCCGTCTTGCTGAAGTTGGTTGATCAGGATCCTAGCCTCATCGCCCGCATCAGTTCTCTGGT
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3LID1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3K789

References