89395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1271648..1272189 Replicon chromosome
Accession NZ_CP024978
Organism Escherichia coli strain CV839-15

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag CV83915_RS09460 Protein ID WP_000615979.1
Coordinates 1271911..1272189 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag CV83915_RS09455 Protein ID WP_000729704.1
Coordinates 1271648..1271908 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV83915_RS09425 1266887..1267942 - 1056 WP_001226164.1 DNA polymerase IV -
CV83915_RS09430 1268013..1268798 - 786 WP_000207573.1 putative lateral flagellar export/assembly protein LafU -
CV83915_RS09435 1268770..1269900 + 1131 Protein_1284 FHIPEP family type III secretion protein -
CV83915_RS09440 1270005..1270283 + 279 WP_063104680.1 type II toxin-antitoxin system HicA family toxin -
CV83915_RS09445 1270276..1270632 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
CV83915_RS09450 1270689..1271462 - 774 WP_000543899.1 C40 family peptidase -
CV83915_RS09455 1271648..1271908 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
CV83915_RS09460 1271911..1272189 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
CV83915_RS09465 1272345..1273085 + 741 WP_001225679.1 murein L,D-transpeptidase -
CV83915_RS09470 1273056..1273823 - 768 WP_001365365.1 class II glutamine amidotransferase -
CV83915_RS09475 1274029..1274607 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T89395 WP_000615979.1 NZ_CP024978:1271911-1272189 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T89395 NZ_CP024978:1271911-1272189 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT89395 WP_000729704.1 NZ_CP024978:1271648-1271908 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT89395 NZ_CP024978:1271648-1271908 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References