Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2284579..2285098 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2I5KI59
Locus tag CVO91_RS11570 Protein ID WP_002940288.1
Coordinates 2284579..2284836 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2I5KI47
Locus tag CVO91_RS11575 Protein ID WP_002940290.1
Coordinates 2284838..2285098 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS11555 2281210..2282940 - 1731 WP_002940284.1 hypothetical protein -
CVO91_RS11560 2283143..2284051 - 909 WP_079255266.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CVO91_RS11565 2284035..2284565 - 531 WP_002940287.1 DUF1697 domain-containing protein -
CVO91_RS11570 2284579..2284836 - 258 WP_002940288.1 Txe/YoeB family addiction module toxin Toxin
CVO91_RS11575 2284838..2285098 - 261 WP_002940290.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CVO91_RS11580 2285612..2286067 - 456 WP_002940299.1 8-oxo-dGTP diphosphatase -
CVO91_RS11585 2286075..2286623 - 549 WP_033875378.1 hypothetical protein -
CVO91_RS11590 2286635..2286964 - 330 WP_002940309.1 type II toxin-antitoxin system RelE/ParE family toxin -
CVO91_RS11595 2286954..2287241 - 288 WP_002940311.1 hypothetical protein -
CVO91_RS11600 2287338..2287718 - 381 WP_002940320.1 hypothetical protein -
CVO91_RS11605 2287711..2288280 - 570 WP_002940322.1 ribonuclease M5 -
CVO91_RS11610 2288264..2289046 - 783 WP_002940323.1 TatD family hydrolase -
CVO91_RS11615 2289153..2289290 - 138 WP_002939016.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10263.72 Da        Isoelectric Point: 7.2735

>T89372 WP_002940288.1 NZ_CP024974:c2284836-2284579 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVESDRLCILSL
KDHYG

Download         Length: 258 bp

>T89372 NZ_CP024974:c2284836-2284579 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGATGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGCTGATTTATATGGTGGAATCCGATCGGTTGTGCATCCTGTCGCTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9915.29 Da        Isoelectric Point: 6.2218

>AT89372 WP_002940290.1 NZ_CP024974:c2285098-2284838 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQATLAVARNTYLSQKVLRGMAQVKAGQTQER
HLIEAD

Download         Length: 261 bp

>AT89372 NZ_CP024974:c2285098-2284838 [Streptococcus suis]
ATGGAAGCTATAGTGTATTCCCATTTTCGAAACCACTTAAAGGACTATATGAAAAAGGTCAATGATGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGCTTACAGGCAACCCTTG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCAGGGCAAACTCAAGAACGC
CATCTGATAGAGGCGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KI59

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5KI47

References