89366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii(toxin)
Location 7662560..7663923 Replicon chromosome
Accession NZ_CP024972
Organism Amycolatopsis sp. TNS106

Toxin (Protein)


Gene name tglT Uniprot ID -
Locus tag CVV72_RS35445 Protein ID WP_219148480.1
Coordinates 7663099..7663923 (+) Length 275 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID -
Locus tag CVV72_RS35440 Protein ID WP_219148478.1
Coordinates 7662560..7663102 (+) Length 181 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVV72_RS35425 (CVV72_35285) 7659362..7659862 - 501 WP_219148471.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
CVV72_RS35430 (CVV72_35290) 7659862..7661319 - 1458 WP_219148473.1 AlkA N-terminal domain-containing protein -
CVV72_RS35435 (CVV72_35295) 7661425..7662507 + 1083 WP_219148475.1 redox-regulated ATPase YchF -
CVV72_RS35440 (CVV72_35300) 7662560..7663102 + 543 WP_219148478.1 hypothetical protein Antitoxin
CVV72_RS35445 (CVV72_35305) 7663099..7663923 + 825 WP_219148480.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CVV72_RS35450 (CVV72_35310) 7663924..7664292 - 369 WP_219148482.1 hypothetical protein -
CVV72_RS35455 (CVV72_35315) 7664335..7664568 + 234 WP_219148484.1 hypothetical protein -
CVV72_RS35460 (CVV72_35320) 7664565..7664930 + 366 WP_219148486.1 DUF6357 family protein -
CVV72_RS35465 (CVV72_35325) 7664983..7666167 + 1185 WP_255632367.1 DUF6357 family protein -
CVV72_RS35470 (CVV72_35330) 7666164..7667060 + 897 WP_219148490.1 hypothetical protein -
CVV72_RS35475 (CVV72_35335) 7667074..7668135 + 1062 WP_219148492.1 ankyrin repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(47-248)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 275 a.a.        Molecular weight: 30755.85 Da        Isoelectric Point: 4.9130

>T89366 WP_219148480.1 NZ_CP024972:7663099-7663923 [Amycolatopsis sp. TNS106]
VRYSGVPTSVRSLEQRIRNLEGEDGLARRRRISMALVVVGQLLPEGAIKGGSAMALRYGRETRFTQDLDAARVQPLGRFR
GDFEESLVSGWAGFTGRLIEKAAPRPPAVPTAYVMQPFEVKLDYRGRAWCTVKFELGHNEIGDADEPEFHLAEDLADLFT
EVGLETPKPVPVMRADHQIAQKLHAVSSEGNERARDLADLQLLERRESLDLDQIAETCVRLFDYRRQQAWPPSIVVGERW
DTLYAEAAEGLDVLSSVEEAVIWVNDFVRRIAAV

Download         Length: 825 bp

>T89366 NZ_CP024972:7663099-7663923 [Amycolatopsis sp. TNS106]
GTGAGGTATTCCGGCGTGCCGACGAGTGTGCGCTCTTTGGAGCAGCGCATCCGCAACCTCGAAGGTGAAGACGGATTGGC
CCGCCGTCGCCGGATCAGTATGGCGCTGGTGGTCGTCGGCCAGCTGCTGCCCGAAGGAGCGATCAAAGGCGGTAGCGCGA
TGGCGTTGCGCTACGGGCGCGAGACGAGGTTCACTCAGGATCTCGACGCCGCGCGAGTCCAGCCGCTCGGCCGGTTTCGC
GGCGACTTCGAGGAGTCCCTGGTGAGCGGGTGGGCCGGCTTCACCGGCAGATTGATCGAGAAGGCCGCGCCCCGTCCTCC
GGCCGTTCCGACGGCATACGTCATGCAGCCCTTCGAGGTGAAGCTCGATTATCGGGGCAGAGCGTGGTGCACGGTGAAGT
TCGAGCTCGGCCACAACGAGATCGGCGACGCCGACGAGCCGGAGTTCCACCTCGCCGAGGACTTGGCCGATCTCTTCACC
GAAGTCGGCCTCGAAACGCCTAAGCCGGTGCCGGTGATGCGCGCAGACCACCAGATAGCCCAGAAGCTGCACGCCGTTTC
CAGCGAGGGCAACGAGCGTGCGCGCGATCTCGCCGACCTTCAGCTTCTCGAACGACGTGAGAGTCTCGACCTCGACCAGA
TCGCCGAGACGTGCGTACGGCTCTTCGACTATCGGCGGCAGCAGGCATGGCCGCCGTCCATCGTCGTGGGTGAACGGTGG
GACACGCTCTACGCCGAGGCGGCGGAAGGTCTGGATGTGCTGTCGTCGGTCGAAGAGGCGGTCATCTGGGTCAACGACTT
CGTGCGGCGTATCGCCGCCGTCTGA

Antitoxin


Download         Length: 181 a.a.        Molecular weight: 19957.86 Da        Isoelectric Point: 9.2265

>AT89366 WP_219148478.1 NZ_CP024972:7662560-7663102 [Amycolatopsis sp. TNS106]
MAAEVRYRDVVREVAFDNYGYVTTKAAVEAGVPAVELPKLAARGGLENVAYGLYRVPDVPPTRYDQFAEALLRVGDGAYL
HGESVLALFGLADVNPRRIRVAVRRRARPKLPAFVELTQVRGDVRTTYYEGLESQTVAEALLECRGRIEVGRLLAAAEQA
RVEGLLTTAEWRGLRKEIRS

Download         Length: 543 bp

>AT89366 NZ_CP024972:7662560-7663102 [Amycolatopsis sp. TNS106]
ATGGCTGCCGAGGTCAGGTACCGGGACGTCGTTCGCGAGGTAGCGTTCGACAACTACGGGTATGTGACTACGAAAGCCGC
GGTCGAGGCAGGCGTTCCCGCCGTTGAGCTCCCGAAGCTGGCCGCCCGGGGTGGCTTGGAGAACGTCGCTTATGGGCTGT
ATCGCGTGCCGGACGTTCCTCCCACGAGATACGACCAATTCGCCGAGGCGCTCCTCCGTGTCGGCGACGGCGCGTACCTC
CATGGCGAGTCGGTATTGGCACTGTTCGGGCTCGCCGACGTGAACCCCCGGCGGATCCGGGTGGCCGTTCGTCGGCGCGC
GCGTCCGAAGCTGCCGGCCTTTGTCGAGCTGACCCAGGTGAGAGGCGATGTGCGGACGACGTACTACGAGGGGCTCGAGT
CCCAAACCGTCGCCGAGGCGCTCCTCGAGTGTCGTGGACGTATCGAGGTCGGACGTCTTCTGGCCGCCGCCGAGCAAGCG
CGAGTGGAAGGGTTGCTGACGACCGCCGAGTGGCGGGGGCTGAGGAAGGAAATCCGCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References