Detailed information of TA system TA089351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2842875..2843383
• Replicon: chromosome
• Accession: NZ_CP024957
• Organism: Streptomyces cavourensis strain 1AS2a

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: N0CS17
• Locus tag: CVT27_RS12420
• Protein ID: WP_015609077.1
• Coordinates: 2843123..2843383 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CVT27_RS12415
• Protein ID: WP_114931509.1
• Coordinates: 2842875..2843126 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVT27_RS12405	2838639..2840612	-	1974	WP_162888369.1	PQQ-binding-like beta-propeller repeat protein	-
CVT27_RS12410	2840918..2842741	-	1824	WP_119824883.1	ABC-F family ATP-binding cassette domain-containing protein	-
CVT27_RS12415	2842875..2843126	+	252	WP_114931509.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CVT27_RS12420	2843123..2843383	+	261	WP_015609077.1	Txe/YoeB family addiction module toxin	Toxin
CVT27_RS12425	2843371..2844816	-	1446	WP_119824885.1	acyltransferase family protein	-
CVT27_RS12435	2845063..2845806	+	744	WP_162888370.1	hypothetical protein	-
CVT27_RS12440	2845845..2846441	-	597	WP_119828075.1	XRE family transcriptional regulator	-
CVT27_RS12445	2846629..2847345	+	717	WP_119824891.1	class I SAM-dependent methyltransferase	-
CVT27_RS12450	2847387..2847884	+	498	WP_119824893.1	DinB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10452.79 Da
• Isoelectric Point: 9.4245

>T89351 WP_015609077.1 NZ_CP024957:2843123-2843383 [Streptomyces cavourensis]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T89351 NZ_CP024957:2843123-2843383 [Streptomyces cavourensis]
GTGAAGTTCGTATGGGATCAGTCGTCCTGGGACGACTACGTCTGGTGGCAGAACCAGGACCGCAAGATCCTCAAGCGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAGGGCATGGGCAAGCCGGAGCCCCTGAAGCACGGATTCCAGG
GGTACTGGTCGCGCCGCATCACCGATGAGCACCGGCTCATCTACAAGGTGGTCGACGACGAGGTGCGTGTCGCCGCCTGC
CGCTACCACTACGGGCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9313.44 Da
• Isoelectric Point: 4.6892

>AT89351 WP_114931509.1 NZ_CP024957:2842875-2843126 [Streptomyces cavourensis]
MRTMTYTESRAKYAETLSAVVNDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIERLESGGGTVRE
LAE

Nucleotide

• Length: 252 bp

>AT89351 NZ_CP024957:2842875-2843126 [Streptomyces cavourensis]
ATGCGCACGATGACCTACACCGAGTCGCGGGCGAAGTACGCGGAAACCCTGAGCGCGGTCGTGAACGACCGCGAGGAGGT
CGTGGTCACGCGGGCGGGCCATGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCGCTCAAGGAGACCGCGTACC
AGCTCCGCAGCCCGGAGAACGCCCGTCGGCTGCTGGCCTCCATCGAGCGCCTGGAGAGCGGGGGCGGCACGGTGCGGGAG
CTGGCGGAGTGA

Structures

Toxin

• AlphaFold DB: N0CS17