Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4859652..4860309 Replicon chromosome
Accession NZ_CP024956
Organism Pectobacterium atrosepticum strain 36A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CVS35_RS22005 Protein ID WP_039294444.1
Coordinates 4859652..4860023 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CVS35_RS22010 Protein ID WP_039294447.1
Coordinates 4860010..4860309 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS35_RS21985 4855908..4857056 - 1149 WP_039294433.1 galactonate dehydratase -
CVS35_RS21990 4857053..4857670 - 618 WP_039294435.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
CVS35_RS21995 4857654..4858550 - 897 WP_039294438.1 2-dehydro-3-deoxygalactonokinase -
CVS35_RS22000 4858547..4859245 - 699 WP_039294441.1 D-galactonate utilization transcriptional regulator DgoR -
CVS35_RS22005 4859652..4860023 + 372 WP_039294444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVS35_RS22010 4860010..4860309 + 300 WP_039294447.1 XRE family transcriptional regulator Antitoxin
CVS35_RS22015 4860347..4862146 - 1800 WP_039294450.1 ABC transporter ATP-binding protein -
CVS35_RS22020 4862186..4863094 - 909 WP_039294453.1 ABC transporter permease -
CVS35_RS22025 4863091..4864068 - 978 WP_039294455.1 ABC transporter permease -
CVS35_RS22030 4864068..4865039 - 972 WP_039294457.1 nucleoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14160.08 Da        Isoelectric Point: 4.8590

>T89350 WP_039294444.1 NZ_CP024956:4859652-4860023 [Pectobacterium atrosepticum]
MAWKIVTRDLFDTWFDEQTEAVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IVLCAGDKKGEDEKLFYERMIKIADAEFTSHLISPEVKEDGDA

Download         Length: 372 bp

>T89350 NZ_CP024956:4859652-4860023 [Pectobacterium atrosepticum]
TTGGCATGGAAAATAGTAACACGGGATCTATTCGATACTTGGTTTGATGAGCAAACCGAAGCGGTACAGGAAGAGGTTTT
GGCACACCTCGCAATACTCGAAGAGGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTAAAGGTTCAAAATACA
AAAATATGAAGGAGCTGCGGGTTCAGGTTGGAGGCCACCCATTCCGAACATTCTTCGCGTTTGACCGGACACGTAAAGCG
ATTGTTTTATGTGCAGGAGATAAGAAAGGCGAGGATGAAAAATTGTTCTACGAACGTATGATTAAGATCGCAGACGCTGA
GTTTACATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11019.09 Da        Isoelectric Point: 10.8728

>AT89350 WP_039294447.1 NZ_CP024956:4860010-4860309 [Pectobacterium atrosepticum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELKMSQTQLAAALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPNGKRIALTL

Download         Length: 300 bp

>AT89350 NZ_CP024956:4860010-4860309 [Pectobacterium atrosepticum]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGTGCCCGTATTGAGGCGCGCACGGCTGAGATCCG
CCAGGAAATCACTTTAGCGAAACTACGCGAAGAACTGAAAATGTCGCAGACGCAGCTTGCAGCAGCATTGGGGGTCAAGC
AGCCATCTATTGTTAAGATGGAAAAGGTTGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTAACTGCCCTAGGC
GGTAAGCTTACGCTAGATGTGACCCTACCTAATGGTAAGCGTATCGCGCTTACGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References