Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1206555..1207143 Replicon chromosome
Accession NZ_CP024952
Organism Helicobacter pylori strain B125A

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag CV724_RS05835 Protein ID WP_145727252.1
Coordinates 1206862..1207143 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag CV724_RS05830 Protein ID WP_145727251.1
Coordinates 1206555..1206869 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV724_RS05810 1202059..1202715 + 657 WP_145727247.1 ParA family protein -
CV724_RS05815 1202796..1203080 + 285 WP_145727248.1 hypothetical protein -
CV724_RS05820 1203112..1204284 + 1173 WP_145727249.1 hypothetical protein -
CV724_RS05825 1204309..1206219 - 1911 WP_145727250.1 relaxase/mobilization nuclease domain-containing protein -
CV724_RS05830 1206555..1206869 + 315 WP_145727251.1 hypothetical protein Antitoxin
CV724_RS05835 1206862..1207143 + 282 WP_145727252.1 YafQ family addiction module toxin Toxin
CV724_RS05840 1207410..1209146 - 1737 WP_194151169.1 type IV secretory system conjugative DNA transfer family protein -
CV724_RS05845 1209146..1209703 - 558 WP_001167777.1 hypothetical protein -
CV724_RS05850 1209704..1209994 - 291 WP_097692878.1 hypothetical protein -
CV724_RS05855 1209991..1210446 - 456 WP_000795419.1 hypothetical protein -
CV724_RS05860 1210443..1211384 - 942 WP_145727253.1 Flp pilus assembly complex ATPase component TadA -
CV724_RS05865 1211384..1211683 - 300 WP_120864145.1 hypothetical protein -
CV724_RS05870 1211680..1211943 - 264 WP_000564641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10916.90 Da        Isoelectric Point: 10.0258

>T89336 WP_145727252.1 NZ_CP024952:1206862-1207143 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHVLSGRIKESDVASIVDCLKERKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T89336 NZ_CP024952:1206862-1207143 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATGTCTTGTCTGGGCGTATTAAAGAAAGCGA
TGTTGCAAGCATTGTTGATTGCCTCAAAGAGCGAAAACCACTCCAACAAAAATATTGCGACCATGCCTTAAGTGGTAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12282.72 Da        Isoelectric Point: 5.6761

>AT89336 WP_145727251.1 NZ_CP024952:1206555-1206869 [Helicobacter pylori]
MSNIITDYSQYNEKQLQHFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTINSKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT89336 NZ_CP024952:1206555-1206869 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAATTGCAACATTTTTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCTCAAAAACATTCTCAAGAAAAAGAACCCACGCAAAGCCTATTAAATACGATTAACTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTCTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References