Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3137576..3138329 Replicon chromosome
Accession NZ_CP024941
Organism Paraburkholderia terricola strain mHS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CUJ90_RS13940 Protein ID WP_114163062.1
Coordinates 3137576..3137857 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CUJ90_RS13945 Protein ID WP_114163063.1
Coordinates 3137874..3138329 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ90_RS13920 3132924..3133496 + 573 WP_114163567.1 TMEM165/GDT1 family protein -
CUJ90_RS13925 3133667..3134365 - 699 WP_114163060.1 DUF4136 domain-containing protein -
CUJ90_RS13930 3134612..3137317 + 2706 WP_114163061.1 aminopeptidase N -
CUJ90_RS13940 3137576..3137857 + 282 WP_114163062.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUJ90_RS13945 3137874..3138329 + 456 WP_114163063.1 HigA family addiction module antidote protein Antitoxin
CUJ90_RS13950 3138452..3139468 + 1017 WP_073427108.1 class 1 fructose-bisphosphatase -
CUJ90_RS13960 3139766..3140941 - 1176 WP_114163064.1 acyltransferase -
CUJ90_RS13965 3141212..3141412 - 201 WP_114163065.1 hypothetical protein -
CUJ90_RS13970 3141752..3142867 + 1116 WP_073427095.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(23-115)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10546.16 Da        Isoelectric Point: 9.2138

>T89302 WP_114163062.1 NZ_CP024941:3137576-3137857 [Paraburkholderia terricola]
MITTFGDKATARIFQGKFVHSLPLHMQALAHRKLLMIDAASSIHSLHAPPGNRLEALQGRRSGQWSIRIDAQWRICFHFV
DGEALNVEIVDYH

Download         Length: 282 bp

>T89302 NZ_CP024941:3137576-3137857 [Paraburkholderia terricola]
ATGATCACGACATTCGGCGACAAGGCCACGGCGAGAATTTTTCAGGGCAAGTTCGTGCACTCACTGCCGCTTCACATGCA
GGCGCTCGCGCACCGCAAGCTTTTGATGATCGACGCCGCCAGTTCCATCCACAGTCTGCACGCGCCGCCCGGCAACCGGC
TCGAAGCCTTGCAAGGCCGGCGCAGCGGGCAATGGAGTATTCGGATCGATGCGCAATGGCGCATCTGTTTTCATTTTGTC
GACGGAGAGGCGCTGAATGTCGAGATTGTCGACTATCACTGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16322.79 Da        Isoelectric Point: 9.6515

>AT89302 WP_114163063.1 NZ_CP024941:3137874-3138329 [Paraburkholderia terricola]
MVIKRSDLNSIDFSDIDAGDSIPEIHPGEILRSEFLEPLGMSVNALALALRVPAPRINDIVRGKRAISADTALRLERYFG
ASAQFWLHLQIAYDLRVATAAAGEQIEREIEPMPKADRPKMPKVSAEHGRAAALAASLRGNAALGKARGKA

Download         Length: 456 bp

>AT89302 NZ_CP024941:3137874-3138329 [Paraburkholderia terricola]
ATGGTCATCAAACGCTCCGATCTGAACAGCATCGATTTCTCCGACATCGATGCCGGCGACAGCATCCCGGAGATTCATCC
GGGCGAGATTCTGCGCAGCGAGTTTCTGGAGCCGCTCGGCATGTCCGTGAATGCGCTGGCGCTGGCGTTGCGCGTGCCGG
CGCCGCGCATCAATGACATCGTGCGCGGCAAGCGCGCCATCTCCGCGGATACGGCGCTGCGCCTCGAGCGCTACTTCGGT
GCGAGCGCGCAGTTCTGGCTCCATCTGCAAATCGCCTACGATCTGCGCGTCGCCACCGCGGCGGCCGGCGAGCAGATCGA
ACGCGAGATCGAACCCATGCCCAAGGCGGACCGCCCGAAAATGCCGAAAGTGTCGGCCGAGCATGGCCGCGCCGCTGCGC
TTGCGGCCAGTCTCAGAGGCAACGCCGCGCTCGGCAAGGCGCGCGGCAAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References