Detailed information of TA system TA089291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1765113..1765668
• Replicon: chromosome
• Accession: NZ_CP024935
• Organism: Paraburkholderia graminis strain PHS1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: B1G8Y3
• Locus tag: CUJ91_RS26035
• Protein ID: WP_006052375.1
• Coordinates: 1765113..1765364 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CUJ91_RS26040
• Protein ID: WP_029971804.1
• Coordinates: 1765375..1765668 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ91_RS26015	1760545..1761234	-	690	WP_029971796.1	hypothetical protein	-
CUJ91_RS26020	1761487..1763031	+	1545	WP_114157500.1	carbohydrate porin	-
CUJ91_RS26025	1763115..1763987	-	873	WP_029971801.1	LysR family transcriptional regulator	-
CUJ91_RS26030	1764101..1765033	+	933	WP_114157501.1	DMT family transporter	-
CUJ91_RS26035	1765113..1765364	-	252	WP_006052375.1	Txe/YoeB family addiction module toxin	Toxin
CUJ91_RS26040	1765375..1765668	-	294	WP_029971804.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CUJ91_RS26050	1766243..1767019	+	777	WP_006052377.1	GntR family transcriptional regulator	-
CUJ91_RS26055	1767028..1768689	+	1662	WP_006052378.1	malonate decarboxylase subunit alpha	-
CUJ91_RS26060	1768689..1769726	+	1038	WP_114157503.1	triphosphoribosyl-dephospho-CoA synthase	-
CUJ91_RS26065	1769732..1770046	+	315	WP_114157504.1	malonate decarboxylase subunit delta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9879.27 Da
• Isoelectric Point: 6.9470

>T89291 WP_006052375.1 NZ_CP024935:c1765364-1765113 [Paraburkholderia graminis]
MFTDDAWDDYVYWQETDRKVVRKINALLEECRRDPFIGTGKPEPLVGSLSGFWSRRITFADRLVYLPKDGKIYVIACRFH
YDQ

Nucleotide

• Length: 252 bp

>T89291 NZ_CP024935:c1765364-1765113 [Paraburkholderia graminis]
ATGTTTACCGACGACGCCTGGGACGACTACGTGTATTGGCAGGAGACAGATCGCAAGGTCGTCCGCAAGATCAATGCGTT
GCTGGAGGAGTGCCGGCGCGATCCGTTTATCGGCACGGGAAAACCGGAGCCGCTCGTCGGCAGCCTGAGCGGTTTCTGGT
CGCGCCGCATCACGTTTGCCGATCGGCTCGTGTATCTGCCGAAAGATGGAAAGATCTATGTGATCGCATGCCGGTTTCAC
TATGACCAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10810.29 Da
• Isoelectric Point: 9.0637

>AT89291 WP_029971804.1 NZ_CP024935:c1765668-1765375 [Paraburkholderia graminis]
MNVLTYSEARAGFKQAMDEVCRDHAPMLITRQSGENVVMVSLEDFNAMQETLYLLSSSKNAQRLARSIAQLNAGGAAPRE
LLTDEPTQKPQRTRRKG

Nucleotide

• Length: 294 bp

>AT89291 NZ_CP024935:c1765668-1765375 [Paraburkholderia graminis]
ATGAACGTCCTTACTTACAGCGAGGCCCGAGCCGGCTTTAAGCAGGCAATGGATGAAGTCTGCCGCGACCACGCACCGAT
GCTCATCACGAGACAGAGTGGCGAAAACGTGGTGATGGTGTCGCTGGAAGACTTCAACGCGATGCAGGAGACCTTGTACC
TGCTGAGTTCGTCGAAGAATGCCCAGCGGCTCGCGCGATCCATTGCCCAGTTGAATGCCGGCGGTGCGGCCCCGCGCGAA
CTGCTGACCGATGAACCGACACAAAAGCCGCAACGAACACGCCGCAAAGGCTGA

Structures

Toxin

• AlphaFold DB: B1G8Y3