Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3102658..3103411 Replicon chromosome
Accession NZ_CP024934
Organism Paraburkholderia graminis strain PHS1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CUJ91_RS13765 Protein ID WP_029967972.1
Coordinates 3102658..3102939 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CUJ91_RS13770 Protein ID WP_044021311.1
Coordinates 3102956..3103411 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ91_RS13750 3098138..3098710 + 573 WP_006050192.1 TMEM165/GDT1 family protein -
CUJ91_RS13755 3098786..3099484 - 699 WP_114156390.1 DUF4136 domain-containing protein -
CUJ91_RS13760 3099755..3102460 + 2706 WP_114156391.1 aminopeptidase N -
CUJ91_RS13765 3102658..3102939 + 282 WP_029967972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUJ91_RS13770 3102956..3103411 + 456 WP_044021311.1 HigA family addiction module antidote protein Antitoxin
CUJ91_RS13775 3103577..3104593 + 1017 WP_114156392.1 class 1 fructose-bisphosphatase -
CUJ91_RS13785 3104849..3105049 - 201 WP_171800576.1 hypothetical protein -
CUJ91_RS34395 3105725..3105874 + 150 WP_006050185.1 hypothetical protein -
CUJ91_RS13790 3106152..3106748 + 597 WP_029967978.1 chorismate mutase -
CUJ91_RS13795 3106840..3107994 - 1155 WP_029967980.1 DNA polymerase III subunit epsilon -
CUJ91_RS13800 3108186..3108389 - 204 WP_006050182.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-86)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10622.20 Da        Isoelectric Point: 9.1173

>T89286 WP_029967972.1 NZ_CP024934:3102658-3102939 [Paraburkholderia graminis]
MITTFGDKATARIFQGRFVHALPRHIQALAYRKLLMIDAADTVHSLHAPPGNRLEALQGQRSGQWSIRINAQWRICFHFI
DGEALNVEIVDYH

Download         Length: 282 bp

>T89286 NZ_CP024934:3102658-3102939 [Paraburkholderia graminis]
ATGATCACAACATTTGGCGACAAGGCTACGGCAAGAATTTTTCAGGGCAGGTTCGTGCATGCGCTGCCGCGTCATATCCA
GGCGCTCGCGTATCGCAAGCTCCTGATGATCGACGCCGCGGACACCGTCCATAGTTTGCATGCGCCGCCCGGCAACCGGC
TCGAAGCGTTGCAGGGGCAGCGCAGCGGGCAGTGGAGCATCCGGATCAATGCGCAATGGCGCATCTGTTTTCACTTTATC
GACGGCGAGGCGCTGAATGTTGAGATTGTCGACTATCACTGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16163.54 Da        Isoelectric Point: 10.0362

>AT89286 WP_044021311.1 NZ_CP024934:3102956-3103411 [Paraburkholderia graminis]
MVIKRSDLASTDFSGIDTGDSIEEIHPGEILRSEFLEPLGMSVNALALALRVPAPRINDVVRGKRAISADTALRLERYFG
ASAQFWLNLQIAYDLRVATAAAGAQIEREIEPMPKADRPKLPKVSAEHARAAALAASVSGSATAGKVRRKG

Download         Length: 456 bp

>AT89286 NZ_CP024934:3102956-3103411 [Paraburkholderia graminis]
ATGGTCATCAAACGCTCCGATCTGGCCAGCACCGATTTCTCCGGCATCGACACCGGAGACAGCATCGAGGAAATCCATCC
GGGGGAGATTTTGCGCAGCGAATTCCTCGAACCGCTCGGCATGTCCGTCAATGCGCTCGCGCTTGCGTTGCGCGTACCGG
CGCCGCGCATCAACGACGTGGTGCGTGGCAAGCGCGCGATCTCGGCTGACACCGCGCTGCGGCTCGAGCGCTACTTCGGC
GCGAGCGCGCAGTTCTGGCTCAATCTGCAAATCGCCTACGACCTGCGCGTCGCCACGGCTGCGGCGGGCGCGCAGATCGA
ACGCGAGATCGAACCCATGCCGAAGGCCGATCGCCCGAAGCTCCCCAAGGTTTCCGCGGAACATGCGCGCGCCGCGGCGC
TCGCAGCGAGCGTGAGCGGCAGCGCCACGGCGGGCAAGGTCCGGCGCAAAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References