Detailed information of TA system TA089218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 4627116..4627960
• Replicon: chromosome
• Accession: NZ_CP024901
• Organism: Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: Q7N0E6
• Locus tag: PluTT01m_RS20300
• Protein ID: WP_011148078.1
• Coordinates: 4627472..4627960 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: Q7N0E7
• Locus tag: PluTT01m_RS20295
• Protein ID: WP_011148077.1
• Coordinates: 4627116..4627466 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluTT01m_RS20270	4622158..4622757	+	600	WP_011148072.1	hypothetical protein	-
PluTT01m_RS20275	4622768..4623883	+	1116	WP_011148073.1	XRE family transcriptional regulator	-
PluTT01m_RS20280	4624030..4624455	-	426	WP_011148074.1	TonB system transport protein ExbD	-
PluTT01m_RS20285	4624459..4625430	-	972	WP_041381122.1	tonB-system energizer ExbB	-
PluTT01m_RS20290	4625777..4626967	+	1191	WP_011148076.1	cystathionine beta-lyase	-
PluTT01m_RS20295	4627116..4627466	+	351	WP_011148077.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
PluTT01m_RS20300	4627472..4627960	+	489	WP_011148078.1	type II toxin-antitoxin system YhaV family toxin	Toxin
PluTT01m_RS20305	4628105..4628776	+	672	WP_011148079.1	DedA family protein	-
PluTT01m_RS20310	4629176..4630054	+	879	WP_011148080.1	2,5-didehydrogluconate reductase DkgA	-
PluTT01m_RS20315	4630189..4631610	-	1422	WP_011148081.1	cell division protein FtsP	-
PluTT01m_RS20320	4632015..4632743	-	729	WP_011148082.1	1-acylglycerol-3-phosphate O-acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (13-149)

Antitoxin

• PrlF antitoxin (14-114)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 19108.94 Da
• Isoelectric Point: 9.5494

>T89218 WP_011148078.1 NZ_CP024901:4627472-4627960 [Photorhabdus laumondii subsp. laumondii]
MYDRVCVINGWALFAHPCFVEQLKQSIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPNDPTNIAFRLGDTLGGKR
KHWFRAKFFQQYRLFFRFHAESKIIIFGWVNDERTKRAYGDKHDAYKVFGEMLNAGHPPDDWNSLLKESIDSPHLTKLIN
EH

Nucleotide

• Length: 489 bp

>T89218 NZ_CP024901:4627472-4627960 [Photorhabdus laumondii subsp. laumondii]
ATGTATGATCGAGTATGTGTAATAAACGGATGGGCTCTTTTTGCTCATCCGTGCTTTGTAGAACAATTAAAACAATCAAT
AGATAAGGTAGAACAACTTCAACAAAAATATCCAAATGACTACTTGAAAAAAAATGATACAAAACGCTTGGCTGCAATCA
TAAAACTCGTTACTGAAATTATTCCCAATGACCCAACTAATATAGCCTTTCGTTTAGGTGACACATTAGGTGGCAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTTTTCCGTTTTCACGCTGAAAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGAGAGAACAAAAAGGGCATATGGTGATAAGCACGATGCTTACAAAGTATTTGGTGAAATGCTTA
ATGCAGGACACCCACCAGACGACTGGAACTCTCTTTTAAAAGAATCCATTGATTCACCACACTTAACTAAACTTATTAAT
GAACATTAG

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12842.53 Da
• Isoelectric Point: 4.9246

>AT89218 WP_011148077.1 NZ_CP024901:4627116-4627466 [Photorhabdus laumondii subsp. laumondii]
MHALPNVEFEVGAESKLTSRSQTTIPTSVRKALKLKPGHDSIAYKILSSGDVLISRKNSEEEKDLVMESFLDFLAKDIRR
HPGQVQQLDEQLINQAKSLIAGIDIDLSNPLSADDE

Nucleotide

• Length: 351 bp

>AT89218 NZ_CP024901:4627116-4627466 [Photorhabdus laumondii subsp. laumondii]
ATGCACGCATTACCAAATGTTGAGTTCGAGGTTGGTGCAGAATCCAAGCTTACCAGTCGCAGCCAGACAACCATCCCAAC
ATCTGTCCGTAAAGCGCTTAAGTTAAAACCAGGTCATGACAGTATCGCATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGCCGTAAAAATAGTGAAGAAGAAAAAGATCTTGTCATGGAATCATTTCTGGACTTTCTGGCAAAAGACATTCGGAGA
CATCCGGGACAAGTACAACAATTAGATGAACAACTCATTAACCAGGCGAAGTCACTTATCGCTGGAATAGACATAGATCT
GAGCAACCCATTATCTGCTGACGATGAGTAA

Structures

Toxin

• AlphaFold DB: A0A6L9JMX9

Antitoxin

• AlphaFold DB: A0A6L9JML2