Detailed information of TA system TA089202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 2485288..2485938
• Replicon: chromosome
• Accession: NZ_CP024901
• Organism: Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q7N558
• Locus tag: PluTT01m_RS10890
• Protein ID: WP_011146354.1
• Coordinates: 2485603..2485938 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PluTT01m_RS10885
• Protein ID: WP_011146353.1
• Coordinates: 2485288..2485602 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluTT01m_RS10860	2480558..2481295	-	738	WP_011146348.1	cyclase family protein	-
PluTT01m_RS10865	2481899..2482453	+	555	WP_011146349.1	cytochrome b	-
PluTT01m_RS10870	2482480..2483058	+	579	WP_011146350.1	YceI family protein	-
PluTT01m_RS10875	2483372..2483740	-	369	WP_011146351.1	hypothetical protein	-
PluTT01m_RS10880	2484709..2485272	+	564	WP_011146352.1	VOC family protein	-
PluTT01m_RS10885	2485288..2485602	-	315	WP_011146353.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PluTT01m_RS10890	2485603..2485938	-	336	WP_011146354.1	hypothetical protein	Toxin
PluTT01m_RS10895	2485993..2486151	+	159	Protein_2060	VOC family protein	-
PluTT01m_RS10900	2486289..2487035	+	747	WP_011146355.1	copper homeostasis protein CutC	-
PluTT01m_RS10905	2487211..2488182	-	972	WP_011146356.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
PluTT01m_RS10910	2488179..2488937	-	759	WP_011146357.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
PluTT01m_RS10915	2489210..2489461	+	252	WP_011146358.1	plasmid stabilization protein	-
PluTT01m_RS10920	2489451..2489741	+	291	WP_011146359.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PluTT01m_RS10925	2489868..2490263	-	396	WP_011146360.1	MAPEG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (13-98)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13393.51 Da
• Isoelectric Point: 10.1960

>T89202 WP_011146354.1 NZ_CP024901:c2485938-2485603 [Photorhabdus laumondii subsp. laumondii]
MEAVFIELPPFERYRHNYLSDEEFRTFQNMLLKNPTTGDVIQHTGGLRKVRFTDSRRKKGKRGGIRIIYYWWVSKSQFML
FTIYDKDEMSDLTKEQCESLRKMLEMRKKGA

Nucleotide

• Length: 336 bp

>T89202 NZ_CP024901:c2485938-2485603 [Photorhabdus laumondii subsp. laumondii]
ATGGAAGCTGTTTTTATTGAACTACCACCTTTTGAACGTTACCGTCATAACTACCTGAGTGATGAGGAGTTTCGAACCTT
CCAAAATATGCTACTGAAAAATCCAACAACAGGAGATGTAATCCAACATACAGGCGGATTGCGTAAAGTACGTTTTACTG
ATTCCCGAAGGAAAAAGGGAAAACGAGGCGGTATTCGGATAATTTACTATTGGTGGGTATCTAAATCGCAATTCATGCTT
TTCACTATCTATGATAAAGATGAAATGTCAGACTTAACTAAAGAGCAATGCGAATCCTTGCGTAAAATGTTAGAAATGAG
AAAAAAAGGAGCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12059.89 Da
• Isoelectric Point: 10.1310

>AT89202 WP_011146353.1 NZ_CP024901:c2485602-2485288 [Photorhabdus laumondii subsp. laumondii]
MKRDLFAELNEGMKAWEEANEGKLTLKTHKRRLKNDIFISPDELKSIRSKLNISQAVFAQYLHTGETTYQNWEQGRAKPN
KQAVLLIKMVERNPQALEFLASLT

Nucleotide

• Length: 315 bp

>AT89202 NZ_CP024901:c2485602-2485288 [Photorhabdus laumondii subsp. laumondii]
ATGAAGCGTGATCTATTTGCAGAACTCAATGAAGGGATGAAAGCTTGGGAAGAGGCTAACGAAGGCAAACTCACATTGAA
AACTCATAAGAGGAGGTTAAAAAATGATATCTTCATCAGTCCGGATGAGTTGAAATCTATCCGGAGTAAACTGAATATTT
CTCAGGCTGTTTTTGCCCAGTACCTGCATACCGGTGAGACGACATACCAAAACTGGGAACAGGGACGGGCTAAACCGAAT
AAACAAGCTGTGTTACTGATTAAAATGGTGGAGCGCAACCCGCAGGCACTAGAATTTCTTGCCAGCCTCACATAA

Structures

Toxin

• AlphaFold DB: A0A6L9JGM0