Detailed information of TA system TA089168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 2467157..2467807
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q7N558
• Locus tag: PluDJC_RS11245
• Protein ID: WP_011146354.1
• Coordinates: 2467472..2467807 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PluDJC_RS11240
• Protein ID: WP_011146353.1
• Coordinates: 2467157..2467471 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS11215	2462532..2463269	-	738	WP_058588603.1	cyclase family protein	-
PluDJC_RS11220	2463872..2464426	+	555	WP_011146349.1	cytochrome b	-
PluDJC_RS11225	2464453..2465031	+	579	WP_109791519.1	YceI family protein	-
PluDJC_RS11230	2465345..2465713	-	369	WP_011146351.1	hypothetical protein	-
PluDJC_RS11235	2466578..2467141	+	564	WP_109791520.1	VOC family protein	-
PluDJC_RS11240	2467157..2467471	-	315	WP_011146353.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PluDJC_RS11245	2467472..2467807	-	336	WP_011146354.1	hypothetical protein	Toxin
PluDJC_RS11250	2467862..2468020	+	159	Protein_2141	VOC family protein	-
PluDJC_RS11255	2468158..2468904	+	747	WP_011146355.1	copper homeostasis protein CutC	-
PluDJC_RS11260	2469080..2470051	-	972	WP_011146356.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
PluDJC_RS11265	2470048..2470806	-	759	WP_011146357.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
PluDJC_RS11270	2471079..2471330	+	252	WP_011146358.1	plasmid stabilization protein	-
PluDJC_RS11275	2471320..2471610	+	291	WP_011146359.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PluDJC_RS11280	2471737..2472132	-	396	WP_011146360.1	MAPEG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (13-98)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13393.51 Da
• Isoelectric Point: 10.1960

>T89168 WP_011146354.1 NZ_CP024900:c2467807-2467472 [Photorhabdus laumondii subsp. laumondii]
MEAVFIELPPFERYRHNYLSDEEFRTFQNMLLKNPTTGDVIQHTGGLRKVRFTDSRRKKGKRGGIRIIYYWWVSKSQFML
FTIYDKDEMSDLTKEQCESLRKMLEMRKKGA

Nucleotide

• Length: 336 bp

>T89168 NZ_CP024900:c2467807-2467472 [Photorhabdus laumondii subsp. laumondii]
ATGGAAGCTGTTTTTATTGAACTACCACCTTTTGAACGTTACCGTCATAACTACCTGAGTGATGAGGAGTTTCGAACCTT
CCAAAATATGCTGCTGAAAAATCCAACAACAGGAGATGTAATCCAACATACAGGCGGATTGCGTAAAGTACGTTTTACTG
ATTCCCGAAGGAAAAAGGGAAAACGAGGCGGTATTCGGATAATTTACTATTGGTGGGTATCTAAATCGCAATTCATGCTT
TTCACTATCTATGATAAAGATGAAATGTCAGACTTAACTAAAGAGCAATGCGAATCCTTGCGTAAAATGTTAGAAATGAG
AAAAAAAGGAGCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12059.89 Da
• Isoelectric Point: 10.1310

>AT89168 WP_011146353.1 NZ_CP024900:c2467471-2467157 [Photorhabdus laumondii subsp. laumondii]
MKRDLFAELNEGMKAWEEANEGKLTLKTHKRRLKNDIFISPDELKSIRSKLNISQAVFAQYLHTGETTYQNWEQGRAKPN
KQAVLLIKMVERNPQALEFLASLT

Nucleotide

• Length: 315 bp

>AT89168 NZ_CP024900:c2467471-2467157 [Photorhabdus laumondii subsp. laumondii]
ATGAAGCGTGATCTATTTGCAGAACTCAATGAAGGGATGAAAGCTTGGGAAGAGGCTAACGAAGGCAAACTCACATTGAA
AACTCATAAGAGGAGGTTAAAAAATGATATCTTCATCAGTCCGGATGAGTTGAAATCTATCCGGAGTAAACTGAATATTT
CTCAGGCTGTTTTTGCCCAGTACCTGCATACCGGTGAGACGACATACCAAAACTGGGAACAGGGACGGGCTAAACCGAAT
AAACAAGCTGTGTTACTGATTAAAATGGTGGAGCGCAACCCGCAGGCACTAGAATTTCTTGCCAGCCTCACATAA

Structures

Toxin

• AlphaFold DB: A0A6L9JGM0