Detailed information of TA system TA089167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2124464..2125092
• Replicon: chromosome
• Accession: NZ_CP024900
• Organism: Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6L9JDM3
• Locus tag: PluDJC_RS09550
• Protein ID: WP_058589469.1
• Coordinates: 2124464..2124751 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PluDJC_RS09555
• Protein ID: WP_011146089.1
• Coordinates: 2124766..2125092 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PluDJC_RS09525	2119936..2121447	-	1512	WP_113049580.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
PluDJC_RS09530	2121751..2122584	+	834	WP_011146084.1	MurR/RpiR family transcriptional regulator	-
PluDJC_RS09535	2122793..2123152	+	360	WP_058589470.1	hypothetical protein	-
PluDJC_RS09540	2123297..2123632	+	336	WP_011146086.1	tRNA-binding protein	-
PluDJC_RS09545	2123689..2124396	+	708	WP_058589488.1	AraC family transcriptional regulator	-
PluDJC_RS09550	2124464..2124751	+	288	WP_058589469.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PluDJC_RS09555	2124766..2125092	+	327	WP_011146089.1	HigA family addiction module antidote protein	Antitoxin
PluDJC_RS09560	2125300..2126838	-	1539	WP_011146090.1	peptide MFS transporter	-
PluDJC_RS09565	2127569..2128510	-	942	WP_109791487.1	LpxL/LpxP family Kdo(2)-lipid IV(A) lauroyl/palmitoleoyl acyltransferasee	-
PluDJC_RS09570	2128797..2129033	+	237	WP_011146092.1	DinI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-94)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (2-98)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11411.05 Da
• Isoelectric Point: 7.2406

>T89167 WP_058589469.1 NZ_CP024900:2124464-2124751 [Photorhabdus laumondii subsp. laumondii]
MAVEFRDRWLERFYEQDLPHKCIPASLQRALYRKLQILDASVKEADLRIPPGNHFEYLNGYLRGWCSIRVNKQYRLIFQW
IDGIAVDTYLDPHND

Nucleotide

• Length: 288 bp

>T89167 NZ_CP024900:2124464-2124751 [Photorhabdus laumondii subsp. laumondii]
ATGGCTGTTGAATTCAGGGATAGATGGCTAGAAAGATTTTATGAACAAGATTTACCGCACAAATGCATACCTGCATCTTT
ACAGCGTGCGTTATACAGAAAACTACAAATTTTGGATGCTTCGGTTAAAGAGGCTGATTTAAGAATCCCTCCGGGAAACC
ATTTTGAATACTTGAATGGCTATTTGAGGGGATGGTGCTCAATAAGAGTAAATAAGCAATATAGGCTTATTTTTCAATGG
ATTGATGGTATTGCGGTTGATACATATCTGGATCCTCATAACGATTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12040.07 Da
• Isoelectric Point: 9.9254

>AT89167 WP_011146089.1 NZ_CP024900:2124766-2125092 [Photorhabdus laumondii subsp. laumondii]
MMRNTKRRPATVGEILVSEFLVPLNIEINVLAEAMGVHRNTLSRIVHDKGSLTVPMAIKLAAALGNTAEFWLNIQHSVEL
WDVRNHAYQAESLNVKQIVKLSVTAAMH

Nucleotide

• Length: 327 bp

>AT89167 NZ_CP024900:2124766-2125092 [Photorhabdus laumondii subsp. laumondii]
ATGATGAGGAATACAAAACGTCGCCCTGCAACAGTGGGTGAAATATTGGTGAGTGAGTTTCTGGTGCCTTTGAATATCGA
AATTAATGTGCTTGCGGAAGCTATGGGTGTTCACCGCAATACATTAAGTAGAATTGTGCATGATAAAGGTTCGCTAACCG
TTCCTATGGCGATCAAATTGGCAGCGGCTTTGGGCAATACAGCGGAGTTTTGGCTTAATATTCAACATTCAGTTGAACTG
TGGGATGTGCGTAATCATGCCTATCAAGCGGAATCACTGAATGTAAAACAGATAGTTAAGCTATCAGTTACAGCGGCAAT
GCACTAA

Structures

Toxin

• AlphaFold DB: A0A6L9JDM3