Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3049589..3050278 Replicon chromosome
Accession NZ_CP024880
Organism Klebsiella aerogenes strain AR_0018

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM345_RS14980 Protein ID WP_042894575.1
Coordinates 3049589..3049885 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM345_RS14985 Protein ID WP_032711784.1
Coordinates 3049943..3050278 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM345_RS14970 3047628..3048773 + 1146 WP_032714650.1 porin OmpC -
AM345_RS14975 3048918..3049352 + 435 WP_015366316.1 universal stress protein UspF -
AM345_RS14980 3049589..3049885 + 297 WP_042894575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM345_RS14985 3049943..3050278 + 336 WP_032711784.1 HigA family addiction module antidote protein Antitoxin
AM345_RS14990 3050317..3050583 + 267 Protein_2789 tyrosine-type recombinase/integrase -
AM345_RS14995 3050631..3051566 + 936 WP_032711785.1 tRNA 2-thiocytidine(32) synthetase TtcA -
AM345_RS15000 3051614..3052987 - 1374 WP_048231211.1 ATP-dependent RNA helicase DbpA -
AM345_RS15010 3053472..3054455 - 984 WP_015366313.1 zinc transporter ZntB -
AM345_RS15015 3054636..3055079 + 444 WP_020078629.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.16 Da        Isoelectric Point: 7.4629

>T89030 WP_042894575.1 NZ_CP024880:3049589-3049885 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHKKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

>T89030 NZ_CP024880:3049589-3049885 [Klebsiella aerogenes]
ATGCAGAATCACATAGGTAGCTTTCGTGATGTATGGTTGGAAGAGTTTTTTTTGCACTCGGCACCACATAAAAAAATTCC
TCCAGACATACATACCACGCTAGCTCGCAAACTCGATATCATCAATGCCGCCGTTACCTATCTGGATTTACGCTCGCCAC
CTGGTAATAGATATGAAGAGCTAAACGGCAAATTGGAAGGTTATTCGTCAATTAGAATTAACCAGCAGTACCGCTTAATA
TTTAAGTGGGTGGATGGAAAAGCGGAAGACCTTTACCTGGATCCGCACAAGTACTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT89030 WP_032711784.1 NZ_CP024880:3049943-3050278 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp

>AT89030 NZ_CP024880:3049943-3050278 [Klebsiella aerogenes]
ATGAAACAGGCAACCAGAAAACCAACTACCGTAGGTGACATCCTGCAGTTTGAATACCTGGAGCCGCTAGATTTAAAAAT
CAACGAACTTGCGGAAATGATACATGTGCATCGTAATAGTGTAAGTGCATTAGTTAACAACAACCGCAAACTAACTACTG
ACATGGCATTTCGCCTGTCTAAAGCCTTCAATACCACCGTTGATTTCTGGCTTAACCTTCAGGCTGCTGTAGATTTGTGG
GAGGTGGAGAATGACACCCGCGCGCAGGAAGAGTTTAGCCGCATTGTTCCCGCCTCGAAATTTATCGCCAGCAAAGCTGA
TAAGAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References