Detailed information of TA system TA088967

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 4890593..4890964
• Replicon: chromosome
• Accession: NZ_CP024862
• Organism: Escherichia coli strain AR_0015

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: AM342_RS25155
• Protein ID: WP_001443846.1
• Coordinates: 4890815..4890964 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	4890593..4890771 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM342_RS25130	4886548..4887921	+	1374	WP_000123748.1	ATP-dependent RNA helicase DbpA	-
AM342_RS25135	4888050..4888985	-	936	WP_001523172.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
AM342_RS25140	4889037..4890272	-	1236	WP_000040839.1	site-specific integrase	-
AM342_RS25145	4890274..4890489	-	216	WP_000079604.1	excisionase XisR	-
AM342_RS25150	4890589..4890777	-	189	WP_001302840.1	DUF1187 family protein	-
-	4890593..4890771	+	179	NuclAT_0	-	Antitoxin
-	4890593..4890771	+	179	NuclAT_0	-	Antitoxin
-	4890593..4890771	+	179	NuclAT_0	-	Antitoxin
-	4890593..4890771	+	179	NuclAT_0	-	Antitoxin
AM342_RS25155	4890815..4890964	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
AM342_RS25160	4891020..4891829	-	810	WP_000166313.1	recombination protein RecT	-
AM342_RS25165	4891822..4894422	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
AM342_RS25170	4894524..4894799	-	276	WP_001344816.1	hypothetical protein	-
AM342_RS25175	4894874..4895044	-	171	WP_001352098.1	conserved protein, Rac prophage	-
AM342_RS25180	4895044..4895265	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4889037..4939464	50427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T88967 WP_001443846.1 NZ_CP024862:c4890964-4890815 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T88967 NZ_CP024862:c4890964-4890815 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT88967 NZ_CP024862:4890593-4890771 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin