Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1699441..1700134 Replicon chromosome
Accession NZ_CP024862
Organism Escherichia coli strain AR_0015

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AM342_RS08575 Protein ID WP_000415584.1
Coordinates 1699838..1700134 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AM342_RS08570 Protein ID WP_000650107.1
Coordinates 1699441..1699836 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM342_RS08560 1695305..1697563 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
AM342_RS08565 1697701..1699308 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
AM342_RS08570 1699441..1699836 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AM342_RS08575 1699838..1700134 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AM342_RS08580 1700339..1700821 - 483 WP_000183505.1 transcriptional regulator -
AM342_RS08585 1700874..1701266 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AM342_RS08590 1701418..1702077 + 660 WP_001221493.1 two-component system response regulator QseB -
AM342_RS08595 1702074..1703423 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
AM342_RS08600 1703469..1703801 - 333 WP_023149630.1 DUF2645 family protein -
AM342_RS08610 1704120..1704701 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AM342_RS08615 1704732..1705046 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T88951 WP_000415584.1 NZ_CP024862:c1700134-1699838 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T88951 NZ_CP024862:c1700134-1699838 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT88951 WP_000650107.1 NZ_CP024862:c1699836-1699441 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT88951 NZ_CP024862:c1699836-1699441 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References