Detailed information of TA system TA088800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 551994..552496
• Replicon: chromosome
• Accession: NZ_CP024842
• Organism: Pectobacterium versatile strain 3-2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: OA04_RS02530
• Protein ID: WP_107332237.1
• Coordinates: 551994..552248 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7W2E625
• Locus tag: OA04_RS02535
• Protein ID: WP_039324900.1
• Coordinates: 552245..552496 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OA04_RS02510	547148..548410	-	1263	WP_103861534.1	L-rhamnose isomerase	-
OA04_RS02515	548407..549897	-	1491	WP_107332236.1	rhamnulokinase	-
OA04_RS02520	550234..551073	+	840	WP_039493893.1	HTH-type transcriptional activator RhaS	-
OA04_RS02525	551098..551952	+	855	WP_040031929.1	helix-turn-helix domain-containing protein	-
OA04_RS02530	551994..552248	-	255	WP_107332237.1	Txe/YoeB family addiction module toxin	Toxin
OA04_RS02535	552245..552496	-	252	WP_039324900.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
OA04_RS02540	552571..554277	-	1707	WP_107332238.1	ABC transporter ATP-binding protein	-
OA04_RS02545	554274..555140	-	867	WP_107332239.1	ABC transporter permease	-
OA04_RS02550	555133..556092	-	960	WP_029367586.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10171.76 Da
• Isoelectric Point: 8.8560

>T88800 WP_107332237.1 NZ_CP024842:c552248-551994 [Pectobacterium versatile]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITGDAMMIAAC
RYHY

Nucleotide

• Length: 255 bp

>T88800 NZ_CP024842:c552248-551994 [Pectobacterium versatile]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGGTGACGCCATGATGATAGCCGCCTGC
CGCTACCACTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9367.64 Da
• Isoelectric Point: 4.6119

>AT88800 WP_039324900.1 NZ_CP024842:c552496-552245 [Pectobacterium versatile]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Nucleotide

• Length: 252 bp

>AT88800 NZ_CP024842:c552496-552245 [Pectobacterium versatile]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W2E625