Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2528541..2529198 Replicon chromosome
Accession NZ_CP024811
Organism Halomonas alkaliphila strain X3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CUU95_RS11635 Protein ID WP_095603866.1
Coordinates 2528854..2529198 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CUU95_RS11630 Protein ID WP_095603867.1
Coordinates 2528541..2528843 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUU95_RS18765 2523941..2524246 - 306 Protein_2250 AraC family ligand binding domain-containing protein -
CUU95_RS11610 2524409..2525302 + 894 WP_120386567.1 dihydrodipicolinate synthase family protein -
CUU95_RS11615 2525368..2526336 - 969 WP_095603870.1 putative zinc-binding metallopeptidase -
CUU95_RS11625 2526860..2528473 + 1614 WP_120386568.1 ATP-binding cassette domain-containing protein -
CUU95_RS11630 2528541..2528843 - 303 WP_095603867.1 XRE family transcriptional regulator Antitoxin
CUU95_RS11635 2528854..2529198 - 345 WP_095603866.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUU95_RS11640 2529484..2529819 + 336 WP_038477126.1 PhnA domain-containing protein -
CUU95_RS11645 2529984..2530406 + 423 WP_205739002.1 GNAT family N-acetyltransferase -
CUU95_RS11650 2530567..2530776 + 210 WP_120386569.1 nucleotidyltransferase family protein -
CUU95_RS11655 2530858..2531556 + 699 WP_120386570.1 alpha/beta hydrolase -
CUU95_RS11670 2532021..2533070 + 1050 WP_120386572.1 DUF2235 domain-containing protein -
CUU95_RS11675 2533217..2533540 + 324 WP_120386573.1 DUF427 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13203.03 Da        Isoelectric Point: 6.2305

>T88564 WP_095603866.1 NZ_CP024811:c2529198-2528854 [Halomonas alkaliphila]
MWSIEQTDTFEAWFFSLEEIERENVLASVLLLRERGPMLSRPHADTVNGSQHSNMKELRVQCQGRPIRVFFAFDPRRTGI
LLCAGDKGGNDKRFYNEMIPVADKEYTAHLETLK

Download         Length: 345 bp

>T88564 NZ_CP024811:c2529198-2528854 [Halomonas alkaliphila]
ATGTGGTCTATCGAGCAAACAGACACATTTGAAGCGTGGTTCTTCTCATTGGAAGAAATTGAACGTGAGAACGTTCTGGC
TTCTGTACTTCTTCTACGTGAACGAGGCCCGATGCTTTCAAGGCCGCACGCTGACACTGTAAATGGCTCGCAGCATTCCA
ACATGAAGGAATTGCGTGTTCAGTGCCAGGGACGTCCTATTAGAGTATTTTTTGCGTTTGACCCACGTCGCACAGGCATC
TTGCTATGCGCAGGCGATAAAGGTGGAAATGACAAGCGCTTCTATAATGAGATGATTCCAGTCGCCGATAAAGAATATAC
GGCTCACCTGGAAACACTAAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10992.78 Da        Isoelectric Point: 6.4757

>AT88564 WP_095603867.1 NZ_CP024811:c2528843-2528541 [Halomonas alkaliphila]
MARKLEDLLAREKPEIVAAAEAKANDMLFEIRLAEIRQLAEKTQADIAIAMGVKQPTVAGLEKVGQDMRLSSLKRYVEAL
GGRVRVDIELPDGSHHGFPV

Download         Length: 303 bp

>AT88564 NZ_CP024811:c2528843-2528541 [Halomonas alkaliphila]
ATGGCACGCAAACTGGAAGACTTGTTAGCAAGAGAAAAGCCAGAGATCGTTGCGGCAGCCGAGGCGAAAGCCAACGATAT
GTTATTCGAGATCAGGCTTGCCGAAATTCGTCAGCTAGCGGAGAAAACCCAAGCAGACATAGCTATTGCGATGGGAGTAA
AACAACCCACCGTCGCAGGACTTGAGAAAGTTGGCCAGGATATGCGCCTTAGTTCACTCAAACGCTACGTCGAAGCGCTA
GGCGGCCGAGTCCGTGTCGATATAGAACTTCCCGATGGAAGTCATCATGGCTTCCCTGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References