Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 556164..556735 Replicon chromosome
Accession NZ_CP024811
Organism Halomonas alkaliphila strain X3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CUU95_RS02610 Protein ID WP_120385715.1
Coordinates 556457..556735 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CUU95_RS02605 Protein ID WP_120385714.1
Coordinates 556164..556457 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUU95_RS02580 551973..553145 + 1173 WP_120385710.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
CUU95_RS02585 553223..554419 + 1197 WP_120385711.1 homoserine O-acetyltransferase -
CUU95_RS02590 554566..554817 + 252 WP_120385712.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CUU95_RS02595 554814..555068 + 255 WP_095602674.1 Txe/YoeB family addiction module toxin -
CUU95_RS02600 555085..556047 - 963 WP_120385713.1 ribonuclease Z -
CUU95_RS02605 556164..556457 - 294 WP_120385714.1 HigA family addiction module antidote protein Antitoxin
CUU95_RS02610 556457..556735 - 279 WP_120385715.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUU95_RS02615 556930..557025 - 96 Protein_506 type II toxin-antitoxin system YoeB family toxin -
CUU95_RS02620 557207..558484 - 1278 WP_120385716.1 short-chain fatty acid transporter -
CUU95_RS02625 558569..559495 - 927 WP_120385717.1 ornithine cyclodeaminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10781.36 Da        Isoelectric Point: 10.1580

>T88562 WP_120385715.1 NZ_CP024811:c556735-556457 [Halomonas alkaliphila]
MIKSFRHKGLKRFYASGSTAGIQADHAKKLRMQLAALDTAVSVEDMDIPGFRLHPLKGRYKARWSIWINGNWRMTFEFRD
GNAYILDYEDYH

Download         Length: 279 bp

>T88562 NZ_CP024811:c556735-556457 [Halomonas alkaliphila]
ATGATTAAATCATTCCGCCACAAGGGACTCAAGCGGTTCTACGCTAGTGGCAGCACCGCTGGTATACAGGCGGATCATGC
CAAGAAATTGCGTATGCAGCTTGCCGCTCTGGACACGGCCGTGTCAGTAGAAGATATGGATATCCCTGGTTTTAGGCTCC
ACCCGTTGAAGGGGAGATACAAAGCGCGGTGGTCAATTTGGATCAACGGAAATTGGCGCATGACGTTCGAATTTCGAGAT
GGCAATGCGTACATTCTTGATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.45 Da        Isoelectric Point: 4.7164

>AT88562 WP_120385714.1 NZ_CP024811:c556457-556164 [Halomonas alkaliphila]
MTMHNPPHPGEFIREVYLEPFGISSRQLASNLGVSPSTLSRLLKGDNGISPEMSLRLSKVLGRTPESWLSMQDMYDLWMA
RSTINLDDLQPLDFEAA

Download         Length: 294 bp

>AT88562 NZ_CP024811:c556457-556164 [Halomonas alkaliphila]
ATGACGATGCATAATCCGCCGCATCCCGGCGAATTTATTCGGGAAGTGTACCTAGAACCTTTTGGTATCAGCTCCCGTCA
GCTTGCTTCCAACTTGGGCGTTTCACCATCCACCTTGTCACGGTTGCTCAAAGGGGATAATGGCATTAGCCCCGAAATGT
CTTTGCGCTTGTCGAAGGTTCTCGGACGTACCCCGGAGAGCTGGCTATCAATGCAGGACATGTATGACCTATGGATGGCT
CGCAGCACAATTAATTTGGACGACCTGCAGCCATTGGACTTTGAGGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References