Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 279274..279776 Replicon chromosome
Accession NZ_CP024811
Organism Halomonas alkaliphila strain X3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CUU95_RS01340 Protein ID WP_120385561.1
Coordinates 279274..279537 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CUU95_RS01345 Protein ID WP_120385562.1
Coordinates 279534..279776 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUU95_RS01315 274677..275075 - 399 WP_009722429.1 6-carboxytetrahydropterin synthase -
CUU95_RS01320 275153..276142 - 990 WP_120385558.1 zinc-binding alcohol dehydrogenase -
CUU95_RS01325 276355..277101 + 747 WP_120385559.1 CDP-alcohol phosphatidyltransferase family protein -
CUU95_RS01330 277602..278162 + 561 WP_038482196.1 manganese efflux pump MntP family protein -
CUU95_RS01335 278316..279137 + 822 WP_120385560.1 aldo/keto reductase -
CUU95_RS01340 279274..279537 - 264 WP_120385561.1 Txe/YoeB family addiction module toxin Toxin
CUU95_RS01345 279534..279776 - 243 WP_120385562.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CUU95_RS01350 279941..280399 - 459 WP_120385563.1 hypothetical protein -
CUU95_RS18625 280514..280687 - 174 WP_167457090.1 hypothetical protein -
CUU95_RS18720 280967..281071 - 105 WP_205739011.1 transposase -
CUU95_RS01365 281489..282217 - 729 WP_120385564.1 nucleotide-binding protein -
CUU95_RS01370 282304..283404 - 1101 WP_120385565.1 hypothetical protein -
CUU95_RS18725 283574..283927 + 354 WP_198348489.1 hypothetical protein -
CUU95_RS18730 283944..284321 + 378 WP_198348490.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10021.67 Da        Isoelectric Point: 9.9105

>T88559 WP_120385561.1 NZ_CP024811:c279537-279274 [Halomonas alkaliphila]
VTWTLVYTKQAQKDAKKLASSGLKPKAQELLALIAEDPYRKPPPFEKPIGDLAGAYSRRINIQHRLVYQVLEDEQVVKVL
RLWSLYE

Download         Length: 264 bp

>T88559 NZ_CP024811:c279537-279274 [Halomonas alkaliphila]
GTGACATGGACGTTGGTTTACACCAAACAAGCCCAGAAGGACGCAAAGAAGCTGGCTTCAAGCGGCCTCAAGCCAAAAGC
CCAAGAGTTGTTGGCCCTAATTGCAGAAGATCCGTACCGAAAGCCGCCCCCGTTTGAGAAGCCCATAGGTGATCTTGCGG
GCGCCTATTCACGCCGCATTAATATTCAGCATCGTTTGGTCTACCAAGTGCTAGAAGACGAGCAAGTAGTGAAAGTCCTC
AGGCTATGGAGCCTCTACGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9074.16 Da        Isoelectric Point: 4.0653

>AT88559 WP_120385562.1 NZ_CP024811:c279776-279534 [Halomonas alkaliphila]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNKAVLVSEEDWSAIQETLYLLSVPGMRESIREGMDTSVDECDEELNW

Download         Length: 243 bp

>AT88559 NZ_CP024811:c279776-279534 [Halomonas alkaliphila]
ATGACCGGAATCACAGCAACGGAGGCGCGGAGCAACCTTTATCGGTTGATTGACGAGACCGCCGAGTCCCACCAACCCAT
CGTCATCATGGGTAAGCGGAACAAAGCCGTCCTGGTTTCCGAGGAAGACTGGTCCGCCATTCAGGAAACGCTTTACCTGC
TCTCCGTACCGGGTATGCGGGAGTCTATTCGTGAGGGAATGGATACCTCCGTGGATGAATGCGATGAGGAGCTGAACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References