Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 7724909..7725498 Replicon chromosome
Accession NZ_CP024785
Organism Nostoc flagelliforme CCNUN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COO91_RS35945 Protein ID WP_100903237.1
Coordinates 7725220..7725498 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COO91_RS35940 Protein ID WP_100902348.1
Coordinates 7724909..7725208 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO91_RS35920 7720875..7721474 + 600 WP_100902345.1 hypothetical protein -
COO91_RS35925 7721519..7723288 + 1770 WP_100902346.1 DEAD/DEAH box helicase -
COO91_RS35930 7723313..7723504 - 192 WP_100902347.1 hypothetical protein -
COO91_RS50220 7723645..7723812 + 168 WP_157816768.1 hypothetical protein -
COO91_RS35935 7724234..7724377 + 144 WP_208766582.1 hypothetical protein -
COO91_RS35940 7724909..7725208 - 300 WP_100902348.1 HigA family addiction module antidote protein Antitoxin
COO91_RS35945 7725220..7725498 - 279 WP_100903237.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COO91_RS35950 7725708..7726088 + 381 WP_100902349.1 hypothetical protein -
COO91_RS35955 7726385..7727260 + 876 Protein_7078 fatty acid desaturase -
COO91_RS35960 7727565..7728059 + 495 Protein_7079 carotenoid biosynthesis protein -
COO91_RS35965 7728373..7728780 - 408 WP_100902350.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10774.99 Da        Isoelectric Point: 6.4844

>T88518 WP_100903237.1 NZ_CP024785:c7725498-7725220 [Nostoc flagelliforme CCNUN1]
VIKTFKHKGLRRLFEFDDRSGIQAKHAEKLLDILDRLDASSQVEDMRYPGSNLHQLKGDRKGEWSVTVSGNWRVTFEFEN
GDAYVVNYEDYH

Download         Length: 279 bp

>T88518 NZ_CP024785:c7725498-7725220 [Nostoc flagelliforme CCNUN1]
GTGATTAAAACGTTTAAGCATAAAGGACTGAGGAGACTTTTTGAGTTTGATGATAGAAGTGGTATTCAGGCTAAACACGC
AGAAAAACTACTAGATATTCTTGATAGACTTGATGCGTCTTCTCAAGTCGAAGATATGAGATACCCAGGTTCTAACCTTC
ATCAGTTAAAAGGTGATAGAAAAGGTGAATGGTCAGTAACGGTATCTGGAAATTGGCGTGTAACCTTTGAATTTGAAAAT
GGTGATGCTTACGTTGTTAATTACGAGGATTATCATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11146.90 Da        Isoelectric Point: 8.0082

>AT88518 WP_100902348.1 NZ_CP024785:c7725208-7724909 [Nostoc flagelliforme CCNUN1]
MITKRRPRHPGALIKRQYLEPLGMTITELGDVLGVSRKTVSELVNEQAGVSPLMAIRLAKAFQTSPELWLNLQQKYDLWN
AVQESESLNDISPVNLQTC

Download         Length: 300 bp

>AT88518 NZ_CP024785:c7725208-7724909 [Nostoc flagelliforme CCNUN1]
ATGATAACTAAAAGAAGACCGAGACACCCCGGAGCGTTGATTAAACGTCAATATTTAGAACCTTTAGGGATGACTATTAC
TGAGCTTGGTGATGTTTTAGGTGTCTCACGTAAAACTGTTTCTGAACTTGTTAATGAGCAAGCTGGAGTTTCTCCACTTA
TGGCTATTCGTCTAGCAAAAGCTTTTCAAACAAGTCCAGAACTTTGGTTAAATCTTCAGCAAAAATACGACCTTTGGAAC
GCTGTACAAGAATCGGAAAGTTTAAACGATATATCTCCTGTTAATTTACAAACTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References