Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5439032..5439653 Replicon chromosome
Accession NZ_CP024785
Organism Nostoc flagelliforme CCNUN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COO91_RS25285 Protein ID WP_100903104.1
Coordinates 5439351..5439653 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COO91_RS25280 Protein ID WP_100900759.1
Coordinates 5439032..5439337 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO91_RS25260 5434299..5435180 - 882 WP_100903102.1 UbiA-like protein EboC -
COO91_RS25265 5435382..5436287 - 906 WP_208766805.1 TatD family hydrolase -
COO91_RS25270 5436437..5437318 - 882 WP_100900757.1 EboA family metabolite traffic protein -
COO91_RS25275 5437790..5438992 + 1203 WP_100900758.1 3-dehydroquinate synthase -
COO91_RS25280 5439032..5439337 - 306 WP_100900759.1 HigA family addiction module antidote protein Antitoxin
COO91_RS25285 5439351..5439653 - 303 WP_100903104.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COO91_RS25290 5439707..5440405 - 699 WP_100900760.1 YdcF family protein -
COO91_RS25295 5440717..5442057 + 1341 WP_100900761.1 S41 family peptidase -
COO91_RS25300 5442200..5443189 + 990 WP_100900762.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(50-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11879.64 Da        Isoelectric Point: 10.2812

>T88514 WP_100903104.1 NZ_CP024785:c5439653-5439351 [Nostoc flagelliforme CCNUN1]
MTSYQPPTRFFWVWKWLFRRWLTHQSNSPSHSWIGVASPSLIDFRIPGIDNKLKVPPGNRLEVLKGDRKGQHSIRINDQY
RICFIWTLQGVSEVEIVDYH

Download         Length: 303 bp

>T88514 NZ_CP024785:c5439653-5439351 [Nostoc flagelliforme CCNUN1]
ATGACCTCATATCAACCTCCAACTCGCTTCTTCTGGGTTTGGAAGTGGCTCTTCAGACGTTGGCTGACTCACCAATCCAA
CTCCCCATCACATTCTTGGATTGGGGTTGCTAGTCCTTCTTTGATAGATTTTCGCATTCCAGGGATAGATAATAAGTTAA
AAGTTCCACCGGGTAACAGGTTAGAAGTACTAAAAGGCGACCGTAAAGGTCAGCATAGCATTCGGATTAATGACCAATAT
CGAATTTGCTTTATATGGACACTCCAGGGTGTATCAGAAGTTGAAATAGTCGATTACCATTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11950.79 Da        Isoelectric Point: 9.8806

>AT88514 WP_100900759.1 NZ_CP024785:c5439337-5439032 [Nostoc flagelliforme CCNUN1]
MRVPKYRPPSHPGEILLKDFLDPMGITQRELADALHVPYQRINELVNQKRGITPSTAIRLSKFFGNSSEFWLNLQQNWKL
YHVLKEEEEELKSILQFRTTK

Download         Length: 306 bp

>AT88514 NZ_CP024785:c5439337-5439032 [Nostoc flagelliforme CCNUN1]
ATGAGAGTTCCAAAGTATAGACCCCCATCACATCCAGGTGAAATATTACTTAAAGATTTTCTAGACCCAATGGGAATAAC
CCAAAGAGAACTTGCAGATGCACTTCACGTTCCTTATCAGCGAATAAATGAGCTTGTAAATCAAAAGCGAGGGATTACAC
CTAGTACGGCAATAAGGTTATCCAAATTTTTTGGAAATAGTTCAGAGTTTTGGTTAAACCTCCAACAGAATTGGAAGCTT
TATCACGTTCTCAAGGAAGAAGAAGAGGAACTAAAAAGTATTTTGCAATTCAGAACTACGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References