Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 601983..602591 Replicon chromosome
Accession NZ_CP024785
Organism Nostoc flagelliforme CCNUN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag COO91_RS02665 Protein ID WP_100897286.1
Coordinates 601983..602267 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COO91_RS02670 Protein ID WP_100897287.1
Coordinates 602283..602591 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO91_RS02650 599025..599909 + 885 WP_100897284.1 serine/threonine protein kinase -
COO91_RS02655 600240..601199 + 960 WP_208766619.1 WD40 repeat domain-containing protein -
COO91_RS02660 601352..601570 - 219 WP_208766620.1 hypothetical protein -
COO91_RS02665 601983..602267 + 285 WP_100897286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COO91_RS02670 602283..602591 + 309 WP_100897287.1 HigA family addiction module antidote protein Antitoxin
COO91_RS02675 602682..602894 - 213 Protein_521 type II toxin-antitoxin system HicB family antitoxin -
COO91_RS02685 603607..603882 + 276 Protein_522 hypothetical protein -
COO91_RS02690 604002..604856 + 855 WP_100897288.1 HIT domain-containing protein -
COO91_RS48480 604935..605096 - 162 WP_157816293.1 hypothetical protein -
COO91_RS02695 605184..605375 + 192 Protein_525 sensor domain-containing diguanylate cyclase -
COO91_RS02700 605963..607543 + 1581 WP_100897289.1 phosphoglycerate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10909.52 Da        Isoelectric Point: 6.9779

>T88511 WP_100897286.1 NZ_CP024785:601983-602267 [Nostoc flagelliforme CCNUN1]
VIVSFKSEETKLIFDGFISSQYPPNIQKTALRKLLIIDAAISINDLRVPPGNRLEKLLGNRKGQYSIRINEQWRICFMWT
DENNASEVEIVDYH

Download         Length: 285 bp

>T88511 NZ_CP024785:601983-602267 [Nostoc flagelliforme CCNUN1]
GTGATTGTTAGTTTTAAATCTGAAGAGACAAAGCTTATCTTTGACGGCTTTATATCTTCTCAGTATCCGCCCAATATCCA
AAAAACTGCTTTACGAAAATTGCTTATTATTGACGCTGCAATATCAATTAACGATTTACGCGTTCCACCTGGTAATCGTT
TAGAAAAGCTACTTGGCAATAGGAAAGGACAGTACAGTATTCGTATTAACGAGCAATGGCGAATCTGCTTTATGTGGACG
GATGAGAACAATGCTTCGGAAGTTGAAATAGTAGATTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11780.29 Da        Isoelectric Point: 4.7063

>AT88511 WP_100897287.1 NZ_CP024785:602283-602591 [Nostoc flagelliforme CCNUN1]
MNNNRLPNIYPGEILQLEFLEPLNITPYRLSKDIGVTQTRISEILSGKRTITADTALRLSRYFGNSAQFWLNLQTQYDIR
QALEENAEVYNQIPTLSFNDVT

Download         Length: 309 bp

>AT88511 NZ_CP024785:602283-602591 [Nostoc flagelliforme CCNUN1]
ATGAACAACAACCGTCTGCCAAATATCTACCCTGGAGAAATCCTACAACTAGAATTTTTAGAGCCACTAAATATCACCCC
TTATCGATTAAGCAAAGATATAGGTGTAACTCAGACAAGAATTAGTGAAATTTTATCTGGAAAACGTACTATTACAGCAG
ATACAGCTTTGCGTTTATCTCGCTATTTTGGTAACAGCGCTCAGTTTTGGTTAAATTTACAAACGCAATACGATATACGT
CAGGCTCTTGAAGAAAATGCAGAAGTTTATAATCAAATACCTACACTTTCATTTAATGATGTAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References