Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3756562..3757255 Replicon chromosome
Accession NZ_CP024659
Organism Escherichia coli strain RM9872-C1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CUB84_RS18510 Protein ID WP_000415584.1
Coordinates 3756959..3757255 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CUB84_RS18505 Protein ID WP_000650107.1
Coordinates 3756562..3756957 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUB84_RS18495 3752426..3754684 - 2259 WP_001281878.1 DNA topoisomerase IV subunit A -
CUB84_RS18500 3754822..3756429 - 1608 WP_001400746.1 ABC transporter substrate-binding protein -
CUB84_RS18505 3756562..3756957 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CUB84_RS18510 3756959..3757255 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CUB84_RS18515 3757460..3757942 - 483 WP_000183497.1 GyrI-like domain-containing protein -
CUB84_RS18520 3757995..3758387 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CUB84_RS18525 3758539..3759198 + 660 WP_001221502.1 two-component system response regulator QseB -
CUB84_RS18530 3759195..3760544 + 1350 WP_000673396.1 two-component system sensor histidine kinase QseC -
CUB84_RS18535 3760626..3760922 - 297 WP_000912118.1 DUF2645 family protein -
CUB84_RS18540 3761280..3761861 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CUB84_RS18545 3761892..3762206 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T88205 WP_000415584.1 NZ_CP024659:c3757255-3756959 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T88205 NZ_CP024659:c3757255-3756959 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGACTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT88205 WP_000650107.1 NZ_CP024659:c3756957-3756562 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT88205 NZ_CP024659:c3756957-3756562 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References