Detailed information of TA system TA088172

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3941342..3941564
• Replicon: chromosome
• Accession: NZ_CP024650
• Organism: Escherichia coli strain BH100 substr. MG2014

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: CDW44_RS20030
• Protein ID: WP_001295224.1
• Coordinates: 3941342..3941449 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3941498..3941564 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDW44_RS20005	3936595..3937347	-	753	Protein_3657	cellulose biosynthesis protein BcsQ	-
CDW44_RS20010	3937359..3937547	-	189	WP_001063314.1	YhjR family protein	-
CDW44_RS20015	3937820..3939391	+	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
CDW44_RS20020	3939388..3939579	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
CDW44_RS20025	3939576..3941255	+	1680	WP_000191565.1	cellulose biosynthesis protein BcsG	-
CDW44_RS20030	3941342..3941449	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3941498..3941564	+	67	-	-	Antitoxin
CDW44_RS20045	3941925..3943196	+	1272	WP_001298005.1	amino acid permease	-
CDW44_RS20050	3943226..3944230	-	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
CDW44_RS20055	3944227..3945210	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
CDW44_RS20060	3945221..3946123	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T88172 WP_001295224.1 NZ_CP024650:c3941449-3941342 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T88172 NZ_CP024650:c3941449-3941342 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT88172 NZ_CP024650:3941498-3941564 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin