Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 15465..15723 Replicon chromosome
Accession NZ_CP024650
Organism Escherichia coli strain BH100 substr. MG2014

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CDW44_RS00080 Protein ID WP_000809168.1
Coordinates 15465..15617 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15666..15723 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDW44_RS00060 10710..11423 - 714 WP_001102393.1 acidic protein MsyB -
CDW44_RS00065 11449..11853 - 405 WP_000843689.1 DUF2541 family protein -
CDW44_RS00070 12225..14141 + 1917 WP_000516135.1 molecular chaperone DnaK -
CDW44_RS00075 14230..15360 + 1131 WP_001118464.1 molecular chaperone DnaJ -
CDW44_RS00080 15465..15617 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15666..15723 + 58 - - Antitoxin
CDW44_RS00090 16232..16993 + 762 WP_099989640.1 hypothetical protein -
CDW44_RS00095 17013..18506 + 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
CDW44_RS00100 18635..19894 + 1260 WP_000494927.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T88149 WP_000809168.1 NZ_CP024650:c15617-15465 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T88149 NZ_CP024650:c15617-15465 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT88149 NZ_CP024650:15666-15723 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1NX00


Antitoxin

Download structure file

References