Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5813689..5814284 Replicon chromosome
Accession NZ_CP024630
Organism Pseudomonas aeruginosa strain PA59

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CPZ93_RS27470 Protein ID WP_071538299.1
Coordinates 5814006..5814284 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CPZ93_RS27465 Protein ID WP_003123432.1
Coordinates 5813689..5813994 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ93_RS33060 5809691..5809756 - 66 Protein_5419 EAL domain-containing protein -
CPZ93_RS27425 5809826..5810053 - 228 WP_153274454.1 hypothetical protein -
CPZ93_RS27430 5810107..5810673 - 567 WP_130027292.1 exonuclease domain-containing protein -
CPZ93_RS27435 5810727..5811218 - 492 WP_130027294.1 hypothetical protein -
CPZ93_RS27440 5811215..5811784 - 570 WP_130027295.1 HAD-IA family hydrolase -
CPZ93_RS27445 5811795..5811998 - 204 WP_130027297.1 hypothetical protein -
CPZ93_RS27450 5812000..5812560 - 561 WP_130027299.1 hypothetical protein -
CPZ93_RS27455 5812591..5813001 + 411 WP_130027301.1 hypothetical protein -
CPZ93_RS27465 5813689..5813994 - 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
CPZ93_RS27470 5814006..5814284 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPZ93_RS27475 5814613..5816841 + 2229 WP_003113525.1 TonB-dependent receptor -
CPZ93_RS27480 5816911..5817558 - 648 WP_003095021.1 carbonate dehydratase -
CPZ93_RS27485 5817620..5818858 - 1239 WP_003123433.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T88116 WP_071538299.1 NZ_CP024630:c5814284-5814006 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T88116 NZ_CP024630:c5814284-5814006 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT88116 WP_003123432.1 NZ_CP024630:c5813994-5813689 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT88116 NZ_CP024630:c5813994-5813689 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References