Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 491684..492947 Replicon chromosome
Accession NZ_CP024601
Organism Porphyromonas gingivalis strain KCOM 2799

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CS387_RS02300 Protein ID WP_097627656.1
Coordinates 491684..492622 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CS387_RS02305 Protein ID WP_097627658.1
Coordinates 492612..492947 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS387_RS02290 486724..488376 - 1653 WP_099895734.1 type I restriction-modification system subunit M -
CS387_RS02295 488382..491615 - 3234 WP_099895736.1 type I restriction endonuclease subunit R -
CS387_RS02300 491684..492622 - 939 WP_097627656.1 HipA domain-containing protein Toxin
CS387_RS02305 492612..492947 - 336 WP_097627658.1 HipA N-terminal domain-containing protein Antitoxin
CS387_RS02310 492944..493168 - 225 WP_097627660.1 helix-turn-helix transcriptional regulator -
CS387_RS02315 493434..493910 - 477 WP_097627697.1 phosphohydrolase -
CS387_RS02320 493914..494234 - 321 WP_097627695.1 helix-turn-helix domain-containing protein -
CS387_RS02325 494330..495292 - 963 WP_097627693.1 hypothetical protein -
CS387_RS02330 495464..497131 - 1668 WP_023847784.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36145.76 Da        Isoelectric Point: 6.1006

>T88049 WP_097627656.1 NZ_CP024601:c492622-491684 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEVDYHAKCCRKLFGMPQAPILPYTSNEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYPHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQIAKLITKYSSVPKLDFVKYWEQVLFSWLIGNADMHLKNYSLYAPIGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFVEAMTASGLDEKVCDNIFARFQRILPEWEACICQSFLPQEMQEQYIQLILDRIHKI

Download         Length: 939 bp

>T88049 NZ_CP024601:c492622-491684 [Porphyromonas gingivalis]
ATGACGAATAGATGCCTATATTGCTACGAACCTTTGGTTGATGGAGAGGTGGATTACCATGCCAAGTGTTGCCGCAAATT
GTTTGGGATGCCCCAAGCACCGATATTGCCCTATACAAGTAACGAAGTACGAGCGTTGGCTGACGAGGTTGTTCGTTCTC
AAACCACAGTGACAGGAGTACAACCCAAGCTGTCTCTCGACTTTGATCAGATGAGCAATTCTCCCAAGCGATTTACCATT
GTGGGCTTGTGGGGTCGGTTTATTCTTAAACCTCAAACGGAGCGTTATCCGCATCTCCCCGAGCTGGAGGATGTATCGAT
GCACCTTGCTGAGATTGCCAAGATAGAAACAGTTCCTCATGGACTGATGCGATTCAGCGATGGCGAACTATGCTACATCA
CTCGTCGTATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGTCAGTTGTCAGAGCGTTTAACGGAG
TATAAATACAAAGGCTCACACGAACAGATAGCCAAGCTGATCACCAAGTATAGCTCTGTGCCGAAGCTTGATTTTGTCAA
GTATTGGGAGCAAGTCCTCTTTTCGTGGTTGATAGGTAATGCCGATATGCACCTTAAGAATTACTCGCTCTATGCGCCAA
TAGGAAACGAATATCAACTAACACCCGCCTACGACCTCCTATCTACGGCTCTCGTTATTCCCGAGGATACAGAAGAACTT
GCACTGACCCTCTGTGGCAAGAAGCGCAAACTCACTCGACAACATTTCGTCGAAGCGATGACAGCCTCTGGACTGGATGA
GAAAGTGTGTGACAACATCTTTGCCCGCTTCCAACGTATCCTCCCCGAATGGGAAGCCTGCATCTGCCAGAGTTTTCTTC
CTCAAGAGATGCAAGAACAGTATATTCAACTGATTCTGGATAGGATTCACAAGATATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12662.49 Da        Isoelectric Point: 4.3108

>AT88049 WP_097627658.1 NZ_CP024601:c492947-492612 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQSISLTMPLREEPFQSNTLHPFFDGLIPEGWLLDIAQKNWKID
ARDRMALLLACCRDCIGAVSIKPLNTTEDDE

Download         Length: 336 bp

>AT88049 NZ_CP024601:c492947-492612 [Porphyromonas gingivalis]
ATGAAACAGGCTATTGTTTATTGGAAGACACTTAAGGCTGGGATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
TGACAAGGACTATTTGACTATGCCTGAAGCTCAAAGCATAAGCCTGACAATGCCTTTGCGAGAAGAGCCATTTCAAAGTA
ATACTCTTCATCCATTCTTTGATGGACTTATCCCTGAGGGATGGCTATTAGATATTGCTCAGAAGAATTGGAAAATAGAT
GCAAGGGATCGCATGGCGTTATTGTTGGCTTGTTGCCGAGACTGTATTGGGGCGGTAAGTATTAAACCTCTAAATACGAC
TGAAGATGACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References