Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 149981..151256 Replicon chromosome
Accession NZ_CP024593
Organism Porphyromonas gingivalis strain KCOM 2804

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CS546_RS00705 Protein ID WP_099811538.1
Coordinates 149981..150931 (-) Length 317 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CS546_RS00710 Protein ID WP_077084039.1
Coordinates 150921..151256 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS546_RS00680 145141..146298 + 1158 WP_097561394.1 IS4-like element IS1598 family transposase -
CS546_RS00685 146399..147264 - 866 Protein_126 type I restriction endonuclease subunit R -
CS546_RS00690 147280..148074 - 795 WP_157761727.1 restriction endonuclease subunit S -
CS546_RS00700 148420..149976 - 1557 WP_099811536.1 N-6 DNA methylase -
CS546_RS00705 149981..150931 - 951 WP_099811538.1 HipA domain-containing protein Toxin
CS546_RS00710 150921..151256 - 336 WP_077084039.1 HipA N-terminal domain-containing protein Antitoxin
CS546_RS00715 151253..151477 - 225 WP_077084038.1 helix-turn-helix transcriptional regulator -
CS546_RS00720 151621..152880 - 1260 WP_099811539.1 HipA domain-containing protein -
CS546_RS00725 152884..153204 - 321 WP_097561577.1 helix-turn-helix domain-containing protein -
CS546_RS00730 153599..154381 - 783 WP_004584112.1 DUF4393 domain-containing protein -
CS546_RS00735 154418..154903 - 486 WP_005874045.1 HU family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 317 a.a.        Molecular weight: 36530.14 Da        Isoelectric Point: 6.1698

>T88047 WP_099811538.1 NZ_CP024593:c150931-149981 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEVDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQISNSPKRFTI
VGLWGRFILKPQTERYPHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYVTRRIDRTEQGEKLPMEDMCQLSERLTE
YKYKGSHEQIAKLITKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPIGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFVEAMIASGLDEKVCDNIFARFQRIIPEWEACVRQSFLTKEMQEQYVALIKYKFEAFNLSV

Download         Length: 951 bp

>T88047 NZ_CP024593:c150931-149981 [Porphyromonas gingivalis]
ATGACGAATAGATGTCTATACTGCTACGAACCTTTGGTTGATGGAGAGGTGGATTACCATGCCAAGTGTTGTCGCAAATT
GTTTGGAACGCCCCAAGCACCGATATTGCCTTATACAAGTAGCGAAGTACGAGCGTTGGCTGACGAGGTCGTTCGTTCGC
AGACCACAGTGACTGGAGTACAACCCAAGCTGTCTCTCGACTTTGATCAGATAAGCAATTCGCCCAAGAGATTTACCATC
GTGGGCTTGTGGGGACGGTTTATTCTTAAACCTCAAACAGAGCGTTATCCGCATCTCCCCGAGTTGGAGGATGTGTCGAT
GCACCTTGCAGAGATTGCCAAGATTGAAACAGTTCCTCATGGACTGATGCGATTCAGCGATGGCGAGCTATGCTATGTCA
CTCGTCGCATAGACAGAACAGAGCAAGGAGAGAAGCTTCCAATGGAAGATATGTGTCAGTTATCAGAGCGTCTGACCGAG
TATAAGTACAAAGGTTCACATGAGCAGATAGCCAAGCTCATCACCAAGTATAGCTCTGTGCCGAAGCTTGATCTTGTCAA
GTATTGGGAGCAGGTTCTCTTTTCGTGGCTGATAGGTAATGCGGATATGCACCTCAAGAATTACTCACTCTATGCTCCAA
TAGGCAACGAATATCAACTAACACCCGCCTATGATCTGCTGTCTACGGCACTTGTTATTCCTGAGGATACGGAAGAGCTT
GCACTGACGCTCTGTGGCAAGAAGCGCAAACTCACCCGCCAACACTTCGTCGAAGCAATGATAGCCTCAGGTCTGGATGA
GAAAGTGTGCGACAACATCTTCGCTCGCTTCCAACGTATCATCCCCGAATGGGAAGCCTGCGTCCGCCAGAGCTTCCTAA
CGAAGGAGATGCAGGAACAGTATGTTGCATTAATAAAATATAAATTTGAAGCATTCAATCTAAGCGTATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12646.49 Da        Isoelectric Point: 4.3108

>AT88047 WP_077084039.1 NZ_CP024593:c151256-150921 [Porphyromonas gingivalis]
MKQAIVYWKSLKAGILTESDEGYSFAYDKDYLTMPEVQGISLTMPLREEPFQSNTLHPFFDGLIPEGWLLDIAQKNWKID
ARDRMALLLACCRDCIGAVSIKPLNTTEDDE

Download         Length: 336 bp

>AT88047 NZ_CP024593:c151256-150921 [Porphyromonas gingivalis]
ATGAAACAAGCTATAGTTTATTGGAAGAGTCTCAAGGCAGGCATCCTCACAGAGAGTGATGAGGGCTATTCCTTTGCTTA
CGACAAGGACTATTTGACTATGCCCGAAGTTCAGGGTATAAGCCTAACGATGCCTTTGCGAGAAGAACCTTTTCAAAGTA
ATACGCTTCATCCATTCTTTGACGGACTTATCCCTGAGGGATGGTTGTTAGATATTGCTCAGAAGAATTGGAAGATAGAC
GCAAGAGATCGAATGGCTTTGCTGTTGGCTTGTTGCCGGGACTGCATTGGAGCGGTAAGTATCAAACCTCTAAATACAAC
TGAAGATGACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References