Detailed information of TA system TA088045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-DinJ
• Location: 1333676..1334195
• Replicon: chromosome
• Accession: NZ_CP024590
• Organism: Enterococcus avium strain FDAARGOS_184

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: AUF16_RS06620
• Protein ID: WP_148712546.1
• Coordinates: 1333676..1333951 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: V5XTW8
• Locus tag: AUF16_RS06625
• Protein ID: WP_002334330.1
• Coordinates: 1333941..1334195 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUF16_RS06585	1329004..1330155	+	1152	WP_148712544.1	IS110 family transposase	-
AUF16_RS06595	1331074..1331394	-	321	WP_148712458.1	hypothetical protein	-
AUF16_RS06605	1332192..1332739	-	548	Protein_1270	recombinase family protein	-
AUF16_RS06610	1332748..1333060	-	313	Protein_1271	BRCT domain-containing protein	-
AUF16_RS06615	1333208..1333639	-	432	WP_148712545.1	hypothetical protein	-
AUF16_RS06620	1333676..1333951	-	276	WP_148712546.1	type II toxin-antitoxin system YafQ family toxin	Toxin
AUF16_RS06625	1333941..1334195	-	255	WP_002334330.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AUF16_RS06630	1334456..1335757	-	1302	WP_148712547.1	ISLre2 family transposase	-
AUF16_RS06635	1335961..1336254	-	294	WP_148712548.1	hypothetical protein	-
AUF16_RS18610	1336603..1336812	+	210	WP_192575115.1	hypothetical protein	-
AUF16_RS06650	1337865..1338137	+	273	WP_192575130.1	hypothetical protein	-
AUF16_RS18615	1338201..1338338	+	138	WP_192575116.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	esp / prgB/asc10	1163492..1362949	199457

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11049.02 Da
• Isoelectric Point: 9.9601

>T88045 WP_148712546.1 NZ_CP024590:c1333951-1333676 [Enterococcus avium]
MKIKRTPTFKRNYKSLKKKHYDMQKLEIVLELLVQQQTDILYQKYKDHALKGNKQGLRELHIEKDWLLVYEIKNEILELW
LLATGKHDDVL

Nucleotide

• Length: 276 bp

>T88045 NZ_CP024590:c1333951-1333676 [Enterococcus avium]
ATGAAGATTAAACGTACTCCCACTTTTAAAAGAAATTACAAATCTCTAAAGAAAAAGCACTATGACATGCAAAAACTAGA
AATTGTCTTAGAATTACTTGTCCAACAACAAACAGATATACTTTATCAAAAGTATAAAGACCATGCATTAAAGGGAAATA
AACAAGGACTTAGAGAATTGCATATTGAAAAAGATTGGCTTCTTGTATACGAAATAAAAAATGAGATTTTAGAATTATGG
TTACTAGCTACTGGAAAGCATGACGATGTTCTTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9747.05 Da
• Isoelectric Point: 4.1501

>AT88045 WP_002334330.1 NZ_CP024590:c1334195-1333941 [Enterococcus avium]
MAQINFRIDDELKEESKEIFDSLGIDLTTGIKIFLTKVVREKGIPFEMTVRKDNLAQALEEMKNEDYKSFDSVAELMKDL
NDED

Nucleotide

• Length: 255 bp

>AT88045 NZ_CP024590:c1334195-1333941 [Enterococcus avium]
ATGGCTCAAATTAACTTTAGAATTGACGATGAATTAAAAGAAGAATCTAAAGAAATCTTTGATTCTCTAGGAATTGATTT
GACAACAGGTATTAAAATATTTTTAACTAAAGTTGTTCGTGAAAAAGGAATTCCTTTTGAAATGACTGTACGAAAAGATA
ATCTTGCTCAAGCATTAGAAGAAATGAAAAATGAAGATTATAAGTCATTTGATAGCGTAGCTGAATTAATGAAGGACTTA
AACGATGAAGATTAA

Structures

Antitoxin

• AlphaFold DB: V5XTW8