Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 30375..31033 Replicon plasmid pAbPK1b
Accession NZ_CP024578
Organism Acinetobacter baumannii strain AbPK1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CTI08_RS20150 Protein ID WP_000312250.1
Coordinates 30674..31033 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CTI08_RS20145 Protein ID WP_099715069.1
Coordinates 30375..30674 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTI08_RS20110 25896..26450 + 555 WP_099715067.1 hypothetical protein -
CTI08_RS20125 28009..28830 + 822 WP_001046004.1 carbapenem-hydrolyzing class D beta-lactamase OXA-23 -
CTI08_RS20130 28935..29594 - 660 Protein_41 ATP-binding protein -
CTI08_RS20145 30375..30674 - 300 WP_099715069.1 helix-turn-helix transcriptional regulator Antitoxin
CTI08_RS20150 30674..31033 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CTI08_RS20155 31234..31800 + 567 WP_000710385.1 hypothetical protein -
CTI08_RS20160 31849..32031 + 183 WP_000373385.1 hypothetical protein -
CTI08_RS20165 32098..32796 + 699 WP_000873188.1 hypothetical protein -
CTI08_RS20170 32935..33318 + 384 WP_000654348.1 hypothetical protein -
CTI08_RS20175 33385..34143 + 759 WP_001053127.1 hypothetical protein -
CTI08_RS20185 35198..35512 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 / aph(3')-VIa - 1..79335 79335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T88042 WP_000312250.1 NZ_CP024578:c31033-30674 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T88042 NZ_CP024578:c31033-30674 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11027.00 Da        Isoelectric Point: 10.5709

>AT88042 WP_099715069.1 NZ_CP024578:c30674-30375 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDIKLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT88042 NZ_CP024578:c30674-30375 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References