Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5521009..5521604 Replicon chromosome
Accession NZ_CP024477
Organism Pseudomonas aeruginosa strain 12939

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CS058_RS26410 Protein ID WP_079380683.1
Coordinates 5521326..5521604 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CS058_RS26405 Protein ID WP_003133769.1
Coordinates 5521009..5521314 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS058_RS31825 5516175..5516456 - 282 WP_128474338.1 hypothetical protein -
CS058_RS26395 5516752..5518959 - 2208 WP_073675111.1 S8 family peptidase -
CS058_RS26400 5518961..5519791 - 831 WP_201266979.1 ATP-binding protein -
CS058_RS26405 5521009..5521314 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
CS058_RS26410 5521326..5521604 - 279 WP_079380683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CS058_RS26420 5521933..5524161 + 2229 WP_003133778.1 TonB-dependent receptor -
CS058_RS26425 5524232..5524879 - 648 WP_003095021.1 carbonate dehydratase -
CS058_RS26430 5524941..5526179 - 1239 WP_023107901.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T87753 WP_079380683.1 NZ_CP024477:c5521604-5521326 [Pseudomonas aeruginosa]
MILTFRCDETRQLFEAGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T87753 NZ_CP024477:c5521604-5521326 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGGCGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT87753 WP_003133769.1 NZ_CP024477:c5521314-5521009 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT87753 NZ_CP024477:c5521314-5521009 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References