Detailed information of TA system TA087753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5521009..5521604
• Replicon: chromosome
• Accession: NZ_CP024477
• Organism: Pseudomonas aeruginosa strain 12939

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CS058_RS26410
• Protein ID: WP_079380683.1
• Coordinates: 5521326..5521604 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CS058_RS26405
• Protein ID: WP_003133769.1
• Coordinates: 5521009..5521314 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS058_RS31825	5516175..5516456	-	282	WP_128474338.1	hypothetical protein	-
CS058_RS26395	5516752..5518959	-	2208	WP_073675111.1	S8 family peptidase	-
CS058_RS26400	5518961..5519791	-	831	WP_201266979.1	ATP-binding protein	-
CS058_RS26405	5521009..5521314	-	306	WP_003133769.1	HigA family addiction module antidote protein	Antitoxin
CS058_RS26410	5521326..5521604	-	279	WP_079380683.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CS058_RS26420	5521933..5524161	+	2229	WP_003133778.1	TonB-dependent receptor	-
CS058_RS26425	5524232..5524879	-	648	WP_003095021.1	carbonate dehydratase	-
CS058_RS26430	5524941..5526179	-	1239	WP_023107901.1	C69 family dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10616.17 Da
• Isoelectric Point: 7.8937

>T87753 WP_079380683.1 NZ_CP024477:c5521604-5521326 [Pseudomonas aeruginosa]
MILTFRCDETRQLFEAGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T87753 NZ_CP024477:c5521604-5521326 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGGCGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11214.73 Da
• Isoelectric Point: 4.6081

>AT87753 WP_003133769.1 NZ_CP024477:c5521314-5521009 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT87753 NZ_CP024477:c5521314-5521009 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG