Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 2667676..2668204 | Replicon | chromosome |
| Accession | NZ_CP024473 | ||
| Organism | Shigella flexneri 7b strain 94-3007 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | CPZ98_RS13235 | Protein ID | WP_005061113.1 |
| Coordinates | 2667974..2668204 (-) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q32DW6 |
| Locus tag | CPZ98_RS13230 | Protein ID | WP_000147081.1 |
| Coordinates | 2667676..2667984 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ98_RS13180 (2662787) | 2662787..2662942 | + | 156 | WP_014532198.1 | type I toxin-antitoxin system toxin HokD | - |
| CPZ98_RS13185 (2663192) | 2663192..2663479 | + | 288 | WP_000687442.1 | hypothetical protein | - |
| CPZ98_RS13190 (2663518) | 2663518..2663886 | + | 369 | Protein_2536 | DUF1367 family protein | - |
| CPZ98_RS13200 (2665151) | 2665151..2665384 | + | 234 | Protein_2538 | DUF1367 family protein | - |
| CPZ98_RS13205 (2665384) | 2665384..2665674 | + | 291 | WP_000228005.1 | DUF1364 domain-containing protein | - |
| CPZ98_RS13210 (2665671) | 2665671..2665781 | + | 111 | Protein_2540 | DUF1133 family protein | - |
| CPZ98_RS13215 (2665858) | 2665858..2667026 | + | 1169 | WP_000747032.1 | IS3-like element IS911 family transposase | - |
| CPZ98_RS13220 (2667051) | 2667051..2667461 | + | 411 | WP_000814621.1 | recombination protein NinB | - |
| CPZ98_RS13225 (2667458) | 2667458..2667634 | + | 177 | WP_001252556.1 | NinE family protein | - |
| CPZ98_RS13230 (2667676) | 2667676..2667984 | - | 309 | WP_000147081.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| CPZ98_RS13235 (2667974) | 2667974..2668204 | - | 231 | WP_005061113.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ98_RS13240 (2668217) | 2668217..2668675 | + | 459 | WP_000961311.1 | ash family protein | - |
| CPZ98_RS13245 (2668733) | 2668733..2669185 | + | 453 | WP_232046050.1 | Rha family transcriptional regulator | - |
| CPZ98_RS13250 (2669182) | 2669182..2669415 | + | 234 | WP_000618004.1 | hypothetical protein | - |
| CPZ98_RS13255 (2669402) | 2669402..2670310 | + | 909 | WP_001247840.1 | hypothetical protein | - |
| CPZ98_RS13260 (2670321) | 2670321..2671199 | + | 879 | WP_000988183.1 | ATP-binding protein | - |
| CPZ98_RS13265 (2671196) | 2671196..2672587 | + | 1392 | WP_000211324.1 | replicative DNA helicase | - |
| CPZ98_RS13270 (2672584) | 2672584..2672841 | + | 258 | WP_001064799.1 | hypothetical protein | - |
| CPZ98_RS13275 (2672936) | 2672936..2673136 | + | 201 | WP_000111769.1 | protein ninH | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | ipaH4.5 | 2615155..2705969 | 90814 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8665.12 Da Isoelectric Point: 10.5308
>T87716 WP_005061113.1 NZ_CP024473:c2668204-2667974 [Shigella flexneri 7b]
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAETRMKEVKHDW
Download Length: 231 bp
>T87716 NZ_CP024473:c2668204-2667974 [Shigella flexneri 7b]
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTCGAACTCAGAATTAAAGG
CAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTGCATAGTTTTGTAAAGAAAG
CGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTCGAACTCAGAATTAAAGG
CAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTGCATAGTTTTGTAAAGAAAG
CGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11185.94 Da Isoelectric Point: 8.5840
>AT87716 WP_000147081.1 NZ_CP024473:c2667984-2667676 [Shigella flexneri 7b]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT87716 NZ_CP024473:c2667984-2667676 [Shigella flexneri 7b]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACACTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACACTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|