Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2168189..2168816 Replicon chromosome
Accession NZ_CP024466
Organism Shigella dysenteriae strain BU53M1

Toxin (Protein)


Gene name higB Uniprot ID A0A828BKW8
Locus tag CPZ97_RS12155 Protein ID WP_024258354.1
Coordinates 2168189..2168518 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q32DW6
Locus tag CPZ97_RS12160 Protein ID WP_000147081.1
Coordinates 2168508..2168816 (+) Length 103 a.a.

Genomic Context

CPZ97_RS12115CPZ97_RS12120CPZ97_RS12125CPZ97_RS12155CPZ97_RS12160CPZ97_RS12180CPZ97_RS12140CPZ97_RS12145CPZ97_RS12150CPZ97_RS12165CPZ97_RS12170CPZ97_RS12185CPZ97_RS12190
Location: 2163454..2164170 (717 bp)
Type: Others
Protein ID: WP_001001693.1
Location: 2164170..2164838 (669 bp)
Type: Others
Protein ID: WP_000464490.1
Location: 2165129..2165449 (321 bp)
Type: Others
Protein ID: Protein_2283
Location: 2168189..2168518 (330 bp)
Type: Toxin
Protein ID: WP_024258354.1
Location: 2168508..2168816 (309 bp)
Type: Antitoxin
Protein ID: WP_000147081.1
Location: 2170859..2171863 (1005 bp)
Type: Others
Protein ID: Protein_2293
Location: 2166216..2166356 (141 bp)
Type: Others
Protein ID: Protein_2285
Location: 2166394..2167116 (723 bp)
Type: Others
Protein ID: WP_134802076.1
Location: 2167191..2167868 (678 bp)
Type: Others
Protein ID: WP_000957540.1
Location: 2168813..2169034 (222 bp)
Type: Others
Protein ID: WP_001254231.1
Location: 2169031..2169441 (411 bp)
Type: Others
Protein ID: WP_000814621.1
Location: 2171921..2172481 (561 bp)
Type: Others
Protein ID: WP_001215754.1
Location: 2172478..2172819 (342 bp)
Type: Others
Protein ID: Protein_2295
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ97_RS121152163454..2164170+717WP_001001693.1arginine ABC transporter permease ArtQ-
CPZ97_RS121202164170..2164838+669WP_000464490.1arginine ABC transporter permease ArtM-
CPZ97_RS121252165129..2165449+321Protein_2283ABC transporter substrate-binding protein ArtJ-
CPZ97_RS121402166216..2166356-141Protein_2285HNH endonuclease-
CPZ97_RS121452166394..2167116-723WP_134802076.1DNA-binding protein-
CPZ97_RS121502167191..2167868-678WP_000957540.1phage antirepressor Ant-
CPZ97_RS121552168189..2168518+330WP_024258354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CPZ97_RS121602168508..2168816+309WP_000147081.1helix-turn-helix transcriptional regulatorAntitoxin
CPZ97_RS121652168813..2169034-222WP_001254231.1NinE family protein-
CPZ97_RS121702169031..2169441-411WP_000814621.1recombination protein NinB-
CPZ97_RS121802170859..2171863+1005Protein_2293tyrosine-type recombinase/integrase-
CPZ97_RS121852171921..2172481-561WP_001215754.1DUF1175 domain-containing protein-
CPZ97_RS121902172478..2172819-342Protein_2295DUF2138 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2155226..220566550439
-insideIScluster/Tn--2158300..217072512425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12837.87 Da        Isoelectric Point: 9.9966

>T87694 WP_024258354.1 NZ_CP024466:2168189-2168518 [Shigella dysenteriae]
MNYTIEYYSEDVRLEVDRLPLSMRARYQHLVERMKIYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFVKKTQKTPPAERKKAETRMKEVKHDW

Download         Length: 330 bp

>T87694 NZ_CP024466:2168189-2168518 [Shigella dysenteriae]
ATGAACTACACTATCGAATACTACAGTGAAGATGTAAGGCTGGAAGTCGATCGGCTTCCATTGAGTATGCGTGCCCGATA
CCAACATCTCGTTGAACGTATGAAGATATATGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGACTTT
TCGAACTCAGAATTAAAGGCAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTG
CATAGTTTTGTAAAGAAAACGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCA
TGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT87694 WP_000147081.1 NZ_CP024466:2168508-2168816 [Shigella dysenteriae]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT87694 NZ_CP024466:2168508-2168816 [Shigella dysenteriae]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACCCTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A828BKW8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7TJC1

References