Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 188696..189237 Replicon chromosome
Accession NZ_CP024466
Organism Shigella dysenteriae strain BU53M1

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag CPZ97_RS00975 Protein ID WP_000615980.1
Coordinates 188696..188974 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag CPZ97_RS00980 Protein ID WP_000729709.1
Coordinates 188977..189237 (-) Length 87 a.a.

Genomic Context

CPZ97_RS00960CPZ97_RS00965CPZ97_RS00985CPZ97_RS00990CPZ97_RS00995CPZ97_RS01000CPZ97_RS01005CPZ97_RS00970CPZ97_RS00975CPZ97_RS00980CPZ97_RS01015
Location: 186278..186856 (579 bp)
Type: Others
Protein ID: WP_005020694.1
Location: 187062..187829 (768 bp)
Type: Others
Protein ID: WP_000333379.1
Location: 189447..190196 (750 bp)
Type: Others
Protein ID: WP_011378552.1
Location: 190372..190689 (318 bp)
Type: Others
Protein ID: Protein_186
Location: 190746..191440 (695 bp)
Type: Others
Protein ID: WP_134801543.1
Location: 191671..192015 (345 bp)
Type: Others
Protein ID: Protein_188
Location: 192070..192767 (698 bp)
Type: Others
Protein ID: Protein_189
Location: 187800..188540 (741 bp)
Type: Others
Protein ID: WP_001225679.1
Location: 188696..188974 (279 bp)
Type: Toxin
Protein ID: WP_000615980.1
Location: 188977..189237 (261 bp)
Type: Antitoxin
Protein ID: WP_000729709.1
Location: 193056..193268 (213 bp)
Type: Others
Protein ID: Protein_190
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ97_RS00960186278..186856+579WP_005020694.1D-sedoheptulose 7-phosphate isomerase-
CPZ97_RS00965187062..187829+768WP_000333379.1class II glutamine amidotransferase-
CPZ97_RS00970187800..188540-741WP_001225679.1murein L,D-transpeptidase-
CPZ97_RS00975188696..188974-279WP_000615980.1type II toxin-antitoxin system mRNA interferase toxin YafQToxin
CPZ97_RS00980188977..189237-261WP_000729709.1type II toxin-antitoxin system antitoxin DinJAntitoxin
CPZ97_RS00985189447..190196+750WP_011378552.1C40 family peptidase-
CPZ97_RS00990190372..190689+318Protein_186transposase-
CPZ97_RS00995190746..191440+695WP_134801543.1IS1 family transposase-
CPZ97_RS01000191671..192015+345Protein_188fimbria/pilus periplasmic chaperone-
CPZ97_RS01005192070..192767+698Protein_189IS1 family transposase-
CPZ97_RS01015193056..193268-213Protein_190helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-gmhA/lpcA / fimC161213..20330642093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T87683 WP_000615980.1 NZ_CP024466:c188974-188696 [Shigella dysenteriae]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T87683 NZ_CP024466:c188974-188696 [Shigella dysenteriae]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAGG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT87683 WP_000729709.1 NZ_CP024466:c189237-188977 [Shigella dysenteriae]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT87683 NZ_CP024466:c189237-188977 [Shigella dysenteriae]
ATGGCTGCAAATGCATTTGTTCGTGCCCGAATCGATGAGGATTTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A090NH48

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829FY17

References