Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1096..1635 Replicon plasmid p48896_3
Accession NZ_CP024432
Organism Klebsiella pneumoniae strain DA48896

Toxin (Protein)


Gene name yafQ Uniprot ID J2DZM3
Locus tag BKL84_RS28605 Protein ID WP_004150484.1
Coordinates 1360..1635 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5H6MLU0
Locus tag BKL84_RS28600 Protein ID WP_001570852.1
Coordinates 1096..1356 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKL84_RS28595 589..846 + 258 WP_050395509.1 hypothetical protein -
BKL84_RS28600 1096..1356 + 261 WP_001570852.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BKL84_RS28605 1360..1635 + 276 WP_004150484.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BKL84_RS29530 1586..1792 + 207 WP_162184628.1 hypothetical protein -
BKL84_RS28610 1789..2451 - 663 WP_106418095.1 hypothetical protein -
BKL84_RS28615 2784..3311 + 528 WP_106418096.1 ankyrin repeat domain-containing protein -
BKL84_RS28620 3322..3531 + 210 WP_106418097.1 hypothetical protein -
BKL84_RS28625 3528..3827 + 300 WP_075829807.1 hypothetical protein -
BKL84_RS28630 3824..4117 + 294 WP_106418098.1 hypothetical protein -
BKL84_RS28635 4193..4576 + 384 WP_152687291.1 hypothetical protein -
BKL84_RS28640 4569..4865 + 297 WP_106418099.1 hypothetical protein -
BKL84_RS28645 4855..5412 + 558 WP_106418100.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
BKL84_RS28650 5428..5967 + 540 WP_106418101.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
BKL84_RS28655 5984..6178 + 195 WP_048242338.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45291 45291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10750.40 Da        Isoelectric Point: 9.6586

>T87657 WP_004150484.1 NZ_CP024432:1360-1635 [Klebsiella pneumoniae]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF

Download         Length: 276 bp

>T87657 NZ_CP024432:1360-1635 [Klebsiella pneumoniae]
ATGACCACAAGGACGATTGAATACTCAGGCCAGTTCCAGAAAGATGTGAAGAAGGCTCAGAAGCGTCATAAAGACATGAG
CAAGCTTAAAGCCCTTATGACGCTGTTAATCAATGATGCCTTGCCATTGCCTCAAGTCTACAAAGATCATCCTCTACAGG
GGAACTACAAAGGCTATAGGGATGCTCACATAGAACCGGACTGGCTACTCATCTACAAGATAACTGATGAAGTCCTACGC
TTTGAGCGAACCGGAACACATTCAGACCTGTTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9239.63 Da        Isoelectric Point: 5.0336

>AT87657 WP_001570852.1 NZ_CP024432:1096-1356 [Klebsiella pneumoniae]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI

Download         Length: 261 bp

>AT87657 NZ_CP024432:1096-1356 [Klebsiella pneumoniae]
ATGGCCGCAAATGCATTTGTTCGTGCTCGTATAGATGAAACACTGAAAAATGAAGCTGCAGTAGTGCTTGCCGGAATGGG
ATTAACCGTTTCCGATCTGGTTCGTATCACTCTGACTAAGGTAGCCAAAGAAAAGGCTCTGCCGTTCGATATGCGTGTTC
CTAACGAGCTTACTGCTAATACCATCGCTAACAGTGAGAAAGGCGTAGACGTTCATACAGCTAAAGATGCTGATGATCTG
TTTAATCAGCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2DZM3

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6MLU0

References