Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2313331..2313923 Replicon chromosome
Accession NZ_CP024311
Organism Rhizobium sp. NXC24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NXC24_RS11395 Protein ID WP_104823382.1
Coordinates 2313642..2313923 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag NXC24_RS11390 Protein ID WP_104825122.1
Coordinates 2313331..2313630 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXC24_RS11380 2308940..2309539 - 600 WP_104823380.1 transcriptional regulator -
NXC24_RS11385 2309536..2313306 - 3771 WP_104823381.1 cobaltochelatase subunit CobN -
NXC24_RS11390 2313331..2313630 - 300 WP_104825122.1 HigA family addiction module antidote protein Antitoxin
NXC24_RS11395 2313642..2313923 - 282 WP_104823382.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NXC24_RS11400 2313981..2315030 - 1050 WP_104825123.1 cobalamin biosynthesis protein CobW -
NXC24_RS11405 2315036..2315563 - 528 WP_104823383.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
NXC24_RS11410 2316286..2318082 + 1797 WP_104823384.1 chloride channel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10517.96 Da        Isoelectric Point: 8.9312

>T87607 WP_104823382.1 NZ_CP024311:c2313923-2313642 [Rhizobium sp. NXC24]
VIVSYKGKFAEAVASGNVPKGFPADLVRSAQRKLTILNYAVVLDDLRSPPGNRLERLQGDRSGQYSIRINDQWRICFLWT
EAGPRDVEIVDYH

Download         Length: 282 bp

>T87607 NZ_CP024311:c2313923-2313642 [Rhizobium sp. NXC24]
GTGATCGTTTCATACAAGGGGAAGTTCGCCGAAGCTGTGGCCTCAGGAAACGTGCCAAAGGGCTTTCCAGCCGACCTCGT
TCGTTCCGCGCAACGCAAGCTGACGATATTGAACTATGCGGTTGTGCTGGACGACCTGCGATCGCCTCCCGGCAATCGGC
TGGAGCGTTTGCAAGGTGATCGTTCTGGCCAGTATTCGATCAGAATCAACGATCAATGGCGCATTTGCTTCCTATGGACC
GAAGCTGGACCGCGTGATGTCGAGATCGTGGATTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10970.68 Da        Isoelectric Point: 5.6939

>AT87607 WP_104825122.1 NZ_CP024311:c2313630-2313331 [Rhizobium sp. NXC24]
MTETKLPPIHPGEILREEYLKPLTMSAGALAKHLNVPRTRIERLVSEDTGVTPDTALRLARFFSTTPDFWMAMQTGYDLA
IAQAEKSDVFAAIKPLEAA

Download         Length: 300 bp

>AT87607 NZ_CP024311:c2313630-2313331 [Rhizobium sp. NXC24]
ATGACCGAGACCAAACTTCCGCCGATCCATCCGGGTGAAATCTTGCGGGAGGAGTATCTGAAGCCATTGACGATGAGCGC
CGGTGCTTTGGCGAAACATCTTAACGTGCCTCGAACGCGTATTGAGAGGCTGGTTTCGGAGGACACCGGGGTCACGCCGG
ATACGGCACTTCGGCTCGCGCGGTTTTTCAGCACGACGCCAGATTTCTGGATGGCGATGCAAACGGGTTATGATCTCGCG
ATCGCGCAAGCGGAAAAGAGCGATGTATTCGCAGCCATCAAGCCGCTTGAAGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References