Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4272930..4273155 Replicon chromosome
Accession NZ_CP024282
Organism Escherichia albertii strain 2014C-4356

Toxin (Protein)


Gene name hokW Uniprot ID A0A7L6L988
Locus tag CCF14_RS21910 Protein ID WP_000813269.1
Coordinates 4272930..4273085 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 4273097..4273155 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF14_RS21860 4268357..4268707 - 351 WP_052931675.1 YdfR family protein -
CCF14_RS21865 4268712..4268927 - 216 WP_000839572.1 class II holin family protein -
CCF14_RS21885 4269727..4270545 - 819 WP_072250181.1 CPBP family intramembrane metalloprotease -
CCF14_RS21890 4270688..4271056 - 369 WP_059217965.1 antitermination protein -
CCF14_RS21895 4271049..4271426 - 378 WP_059274539.1 RusA family crossover junction endodeoxyribonuclease -
CCF14_RS21900 4271427..4272482 - 1056 WP_099588102.1 DUF968 domain-containing protein -
CCF14_RS21905 4272484..4272762 - 279 WP_059274501.1 hypothetical protein -
CCF14_RS21910 4272930..4273085 - 156 WP_000813269.1 type I toxin-antitoxin system toxin HokD Toxin
- 4273097..4273155 + 59 - - Antitoxin
CCF14_RS21915 4273691..4274464 + 774 WP_059274496.1 alpha/beta hydrolase -
CCF14_RS21920 4274820..4275230 - 411 WP_059274497.1 DUF977 family protein -
CCF14_RS21925 4275238..4275999 - 762 WP_059274498.1 DUF1627 domain-containing protein -
CCF14_RS21930 4276023..4276769 - 747 WP_059274499.1 ATP-binding protein -
CCF14_RS21935 4276776..4277738 - 963 WP_072250167.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4243424..4289118 45694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T87543 WP_000813269.1 NZ_CP024282:c4273085-4272930 [Escherichia albertii]
MKQQKAMLVALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T87543 NZ_CP024282:c4273085-4272930 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT87543 NZ_CP024282:4273097-4273155 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6L988

Antitoxin

Download structure file

References