Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2543000..2543246 Replicon chromosome
Accession NZ_CP024282
Organism Escherichia albertii strain 2014C-4356

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag CCF14_RS12895 Protein ID WP_000956458.1
Coordinates 2543094..2543246 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 2543000..2543052 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF14_RS12870 2538404..2540203 + 1800 WP_000211925.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
CCF14_RS12875 2540203..2541915 + 1713 WP_059258555.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
CCF14_RS12885 2542095..2542829 + 735 WP_001125132.1 phosphoadenosine phosphosulfate reductase -
- 2543000..2543052 - 53 - - Antitoxin
CCF14_RS12895 2543094..2543246 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
CCF14_RS12905 2543439..2544551 - 1113 WP_059258553.1 IS4 family transposase -
CCF14_RS12910 2544804..2547461 + 2658 WP_059258551.1 CRISPR-associated helicase/endonuclease Cas3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T87532 WP_000956458.1 NZ_CP024282:2543094-2543246 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T87532 NZ_CP024282:2543094-2543246 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATCGTGCTGTGTTGTACAGTGCTGGGATTCACGTTGATGGTAGGTGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 53 bp

>AT87532 NZ_CP024282:c2543052-2543000 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References