Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1650958..1651215 Replicon chromosome
Accession NZ_CP024282
Organism Escherichia albertii strain 2014C-4356

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag CCF14_RS08325 Protein ID WP_001135738.1
Coordinates 1651063..1651215 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 1650958..1651012 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF14_RS08305 1646188..1647183 - 996 WP_001182625.1 acyltransferase -
CCF14_RS08310 1647356..1647655 + 300 WP_000979961.1 YsaB family lipoprotein -
CCF14_RS08315 1647751..1648662 + 912 WP_024008901.1 glycine--tRNA ligase subunit alpha -
CCF14_RS08320 1648672..1650741 + 2070 WP_001291807.1 glycine--tRNA ligase subunit beta -
- 1650958..1651012 - 55 - - Antitoxin
CCF14_RS08325 1651063..1651215 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
CCF14_RS08330 1651402..1651614 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CCF14_RS08335 1651897..1652187 - 291 WP_000455794.1 HTH-type transcriptional regulator -
CCF14_RS08340 1652610..1653320 + 711 WP_002460072.1 DUF3053 domain-containing protein -
CCF14_RS08345 1653373..1654347 - 975 WP_000804993.1 glyoxylate/hydroxypyruvate reductase GhrB -
CCF14_RS08350 1654451..1655110 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T87526 WP_001135738.1 NZ_CP024282:1651063-1651215 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T87526 NZ_CP024282:1651063-1651215 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT87526 NZ_CP024282:c1651012-1650958 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References