Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3328667..3329360 Replicon chromosome
Accession NZ_CP024275
Organism Escherichia coli O6:H16 strain M9682-C1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag COG40_RS17235 Protein ID WP_000415584.1
Coordinates 3329064..3329360 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag COG40_RS17230 Protein ID WP_000650107.1
Coordinates 3328667..3329062 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG40_RS17220 3324531..3326789 - 2259 WP_001281866.1 DNA topoisomerase IV subunit A -
COG40_RS17225 3326927..3328534 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
COG40_RS17230 3328667..3329062 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
COG40_RS17235 3329064..3329360 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
COG40_RS17240 3329565..3330047 - 483 WP_000183505.1 transcriptional regulator -
COG40_RS17245 3330100..3330492 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
COG40_RS17250 3330644..3331303 + 660 WP_001221493.1 two-component system response regulator QseB -
COG40_RS17255 3331300..3332649 + 1350 WP_000673409.1 two-component system sensor histidine kinase QseC -
COG40_RS17260 3332695..3333027 - 333 WP_000917686.1 DUF2645 family protein -
COG40_RS17270 3333346..3333927 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
COG40_RS17275 3333958..3334272 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T87481 WP_000415584.1 NZ_CP024275:c3329360-3329064 [Escherichia coli O6:H16]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T87481 NZ_CP024275:c3329360-3329064 [Escherichia coli O6:H16]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT87481 WP_000650107.1 NZ_CP024275:c3329062-3328667 [Escherichia coli O6:H16]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT87481 NZ_CP024275:c3329062-3328667 [Escherichia coli O6:H16]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References