Detailed information of TA system TA087461

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 22872..23284
• Replicon: chromosome
• Accession: NZ_CP024275
• Organism: Escherichia coli O6:H16 strain M9682-C1

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: COG40_RS00135
• Protein ID: WP_000132619.1
• Coordinates: 22872..23213 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	23208..23284 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COG40_RS00115	18168..18641	+	474	WP_001531983.1	Rpn family recombination-promoting nuclease/putative transposase	-
COG40_RS00120	18883..20295	-	1413	WP_000199359.1	PLP-dependent aminotransferase family protein	-
COG40_RS00125	20472..20636	+	165	WP_000394281.1	DUF1127 domain-containing protein	-
COG40_RS00130	20732..22825	+	2094	WP_000648235.1	DUF262 domain-containing protein	-
COG40_RS00135	22872..23213	-	342	WP_000132619.1	endoribonuclease SymE	Toxin
-	23208..23284	+	77	NuclAT_34	-	Antitoxin
-	23208..23284	+	77	NuclAT_34	-	Antitoxin
-	23208..23284	+	77	NuclAT_34	-	Antitoxin
-	23208..23284	+	77	NuclAT_34	-	Antitoxin
COG40_RS00140	23442..24680	-	1239	WP_172902795.1	restriction endonuclease subunit S	-
COG40_RS00145	24797..26386	-	1590	WP_001063211.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T87461 WP_000132619.1 NZ_CP024275:c23213-22872 [Escherichia coli O6:H16]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T87461 NZ_CP024275:c23213-22872 [Escherichia coli O6:H16]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAACTGTCAGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT87461 NZ_CP024275:23208-23284 [Escherichia coli O6:H16]
AGTCATAACTGCTATTCTCCTGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin