Detailed information of TA system TA087440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1437694..1438065
• Replicon: chromosome
• Accession: NZ_CP024273
• Organism: Escherichia coli strain F9792

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: A5T63_RS07545
• Protein ID: WP_072130784.1
• Coordinates: 1437871..1438065 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1437694..1437872 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5T63_RS07520	1433649..1435022	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A5T63_RS07525	1435151..1436086	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A5T63_RS07530	1436138..1437373	-	1236	WP_024171493.1	site-specific integrase	-
A5T63_RS07535	1437375..1437590	-	216	WP_000079604.1	excisionase XisR	-
A5T63_RS07540	1437690..1437878	-	189	WP_001302840.1	DUF1187 family protein	-
-	1437694..1437872	+	179	NuclAT_0	-	Antitoxin
-	1437694..1437872	+	179	NuclAT_0	-	Antitoxin
-	1437694..1437872	+	179	NuclAT_0	-	Antitoxin
-	1437694..1437872	+	179	NuclAT_0	-	Antitoxin
A5T63_RS07545	1437871..1438065	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A5T63_RS07550	1438122..1438955	-	834	WP_000166322.1	recombination protein RecT	-
A5T63_RS07555	1438948..1441623	-	2676	WP_001718192.1	exodeoxyribonuclease VIII	-
A5T63_RS07560	1441722..1441997	-	276	WP_001594001.1	phage protein	-
A5T63_RS07565	1442072..1442248	-	177	WP_001594002.1	phage protein	-
A5T63_RS07570	1442242..1442463	-	222	WP_000560220.1	killing protein KilR	-
A5T63_RS07575	1442884..1443036	-	153	WP_001594003.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1436138..1482154	46016

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T87440 WP_072130784.1 NZ_CP024273:c1438065-1437871 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T87440 NZ_CP024273:c1438065-1437871 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGGTGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT87440 NZ_CP024273:1437694-1437872 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin