Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 4849063..4849757 | Replicon | chromosome |
| Accession | NZ_CP024266 | ||
| Organism | Escherichia coli O6:H16 strain F6699 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | COG39_RS23920 | Protein ID | WP_001263493.1 |
| Coordinates | 4849063..4849461 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | COG39_RS23925 | Protein ID | WP_000554757.1 |
| Coordinates | 4849464..4849757 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (4844724) | 4844724..4844804 | - | 81 | NuclAT_12 | - | - |
| - (4844724) | 4844724..4844804 | - | 81 | NuclAT_12 | - | - |
| - (4844724) | 4844724..4844804 | - | 81 | NuclAT_12 | - | - |
| - (4844724) | 4844724..4844804 | - | 81 | NuclAT_12 | - | - |
| COG39_RS23890 (4844064) | 4844064..4845308 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| COG39_RS23895 (4845400) | 4845400..4845858 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| COG39_RS23900 (4846119) | 4846119..4847575 | + | 1457 | Protein_4655 | cytosol nonspecific dipeptidase | - |
| COG39_RS23905 (4847632) | 4847632..4848153 | - | 522 | Protein_4656 | peptide chain release factor H | - |
| COG39_RS23910 (4848152) | 4848152..4848355 | - | 204 | Protein_4657 | RtcB family protein | - |
| COG39_RS23915 (4848601) | 4848601..4849053 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| COG39_RS23920 (4849063) | 4849063..4849461 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| COG39_RS23925 (4849464) | 4849464..4849757 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| COG39_RS23930 (4849809) | 4849809..4850864 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| COG39_RS23935 (4850935) | 4850935..4851858 | - | 924 | WP_001232570.1 | putative lateral flagellar export/assembly protein LafU | - |
| COG39_RS23940 (4851861) | 4851861..4852724 | - | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
| COG39_RS23945 (4852737) | 4852737..4853456 | - | 720 | WP_000938740.1 | FliA/WhiG family RNA polymerase sigma factor | - |
| COG39_RS23950 (4853476) | 4853476..4853943 | - | 468 | WP_000725257.1 | flagellar basal body-associated FliL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T87412 WP_001263493.1 NZ_CP024266:c4849461-4849063 [Escherichia coli O6:H16]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T87412 NZ_CP024266:c4849461-4849063 [Escherichia coli O6:H16]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT87412 WP_000554757.1 NZ_CP024266:c4849757-4849464 [Escherichia coli O6:H16]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT87412 NZ_CP024266:c4849757-4849464 [Escherichia coli O6:H16]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCA
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCA
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|