Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1818503..1819196 Replicon chromosome
Accession NZ_CP024266
Organism Escherichia coli O6:H16 strain F6699

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag COG39_RS08895 Protein ID WP_000415584.1
Coordinates 1818503..1818799 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag COG39_RS08900 Protein ID WP_000650107.1
Coordinates 1818801..1819196 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG39_RS08860 (1813591) 1813591..1813905 - 315 WP_000958598.1 putative quinol monooxygenase -
COG39_RS08865 (1813936) 1813936..1814517 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
COG39_RS08870 (1814836) 1814836..1815168 + 333 WP_000917686.1 DUF2645 family protein -
COG39_RS08875 (1815214) 1815214..1816563 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
COG39_RS08880 (1816560) 1816560..1817219 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
COG39_RS08885 (1817371) 1817371..1817763 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
COG39_RS08890 (1817816) 1817816..1818298 + 483 WP_000183505.1 GyrI-like domain-containing protein -
COG39_RS08895 (1818503) 1818503..1818799 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
COG39_RS08900 (1818801) 1818801..1819196 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
COG39_RS08905 (1819329) 1819329..1820936 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
COG39_RS08910 (1821074) 1821074..1823332 + 2259 WP_001397796.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T87398 WP_000415584.1 NZ_CP024266:1818503-1818799 [Escherichia coli O6:H16]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T87398 NZ_CP024266:1818503-1818799 [Escherichia coli O6:H16]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT87398 WP_000650107.1 NZ_CP024266:1818801-1819196 [Escherichia coli O6:H16]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT87398 NZ_CP024266:1818801-1819196 [Escherichia coli O6:H16]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References