Detailed information of TA system TA087367

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 861945..862316
• Replicon: chromosome
• Accession: NZ_CP024263
• Organism: Escherichia coli O169:H41 strain F6326-C1

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: COG38_RS04625
• Protein ID: WP_072130784.1
• Coordinates: 862122..862316 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	861945..862123 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COG38_RS04600	857900..859273	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
COG38_RS04605	859402..860337	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
COG38_RS04610	860389..861624	-	1236	WP_024171493.1	site-specific integrase	-
COG38_RS04615	861626..861841	-	216	WP_000079604.1	excisionase XisR	-
COG38_RS04620	861941..862129	-	189	WP_001302840.1	DUF1187 family protein	-
-	861945..862123	+	179	NuclAT_0	-	Antitoxin
-	861945..862123	+	179	NuclAT_0	-	Antitoxin
-	861945..862123	+	179	NuclAT_0	-	Antitoxin
-	861945..862123	+	179	NuclAT_0	-	Antitoxin
COG38_RS04625	862122..862316	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
COG38_RS04630	862373..863206	-	834	WP_000166322.1	recombination protein RecT	-
COG38_RS04635	863199..865874	-	2676	WP_001718192.1	exodeoxyribonuclease VIII	-
COG38_RS04640	865973..866248	-	276	WP_001594001.1	phage protein	-
COG38_RS04645	866323..866499	-	177	WP_001594002.1	phage protein	-
COG38_RS04650	866493..866714	-	222	WP_000560220.1	killing protein KilR	-
COG38_RS04655	867135..867287	-	153	WP_001594003.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	860389..906406	46017

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T87367 WP_072130784.1 NZ_CP024263:c862316-862122 [Escherichia coli O169:H41]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T87367 NZ_CP024263:c862316-862122 [Escherichia coli O169:H41]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGGTGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT87367 NZ_CP024263:861945-862123 [Escherichia coli O169:H41]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin