Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 264895..265159 Replicon plasmid unnamed
Accession NZ_CP024238
Organism Escherichia coli O15:H11 strain 90-9272

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag COG31_RS01855 Protein ID WP_001387489.1
Coordinates 264895..265047 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 265099..265159 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG31_RS01830 (260161) 260161..262329 + 2169 WP_099550630.1 DotA/TraY family protein -
COG31_RS01835 (262400) 262400..263062 + 663 WP_099550631.1 plasmid IncI1-type surface exclusion protein ExcA -
COG31_RS01840 (263134) 263134..263343 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
COG31_RS27875 (263735) 263735..263911 + 177 WP_001054900.1 hypothetical protein -
COG31_RS28650 (263976) 263976..264071 - 96 WP_000609148.1 DinQ-like type I toxin DqlB -
COG31_RS01850 (264572) 264572..264823 + 252 WP_001291964.1 hypothetical protein -
COG31_RS01855 (264895) 264895..265047 - 153 WP_001387489.1 Hok/Gef family protein Toxin
- (265099) 265099..265159 + 61 NuclAT_2 - Antitoxin
- (265099) 265099..265159 + 61 NuclAT_2 - Antitoxin
- (265099) 265099..265159 + 61 NuclAT_2 - Antitoxin
- (265099) 265099..265159 + 61 NuclAT_2 - Antitoxin
COG31_RS01860 (265674) 265674..266453 + 780 WP_275450201.1 protein FinQ -
COG31_RS01865 (266760) 266760..267968 + 1209 WP_001303305.1 IncI1-type conjugal transfer protein TrbA -
COG31_RS01870 (267987) 267987..269057 + 1071 WP_099550632.1 IncI1-type conjugal transfer protein TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - etpA / etpB / espC / eltB / eltA / eltA / eltB / csvA 1..274465 274465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T87176 WP_001387489.1 NZ_CP024238:c265047-264895 [Escherichia coli O15:H11]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T87176 NZ_CP024238:c265047-264895 [Escherichia coli O15:H11]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 61 bp

>AT87176 NZ_CP024238:265099-265159 [Escherichia coli O15:H11]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References