Detailed information of TA system TA087056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1299510..1300119
• Replicon: chromosome
• Accession: NZ_CP024185
• Organism: Moraxella osloensis strain TT16

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MOTT16_RS05755
• Protein ID: WP_198510535.1
• Coordinates: 1299781..1300119 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOTT16_RS05750
• Protein ID: WP_036593973.1
• Coordinates: 1299510..1299791 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOTT16_RS05735	1296050..1296928	+	879	WP_099834001.1	RDD family protein	-
MOTT16_RS05740	1296979..1299195	+	2217	WP_099834002.1	FtsW/RodA/SpoVE family cell cycle protein	-
MOTT16_RS05745	1299205..1299453	+	249	WP_099834003.1	hypothetical protein	-
MOTT16_RS05750	1299510..1299791	-	282	WP_036593973.1	helix-turn-helix domain-containing protein	Antitoxin
MOTT16_RS05755	1299781..1300119	-	339	WP_198510535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOTT16_RS05760	1300343..1303195	+	2853	WP_198510536.1	hypothetical protein	-
MOTT16_RS05765	1303221..1304816	+	1596	WP_099834006.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-77)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12820.60 Da
• Isoelectric Point: 9.8468

>T87056 WP_198510535.1 NZ_CP024185:c1300119-1299781 [Moraxella osloensis]
MHFIETPLFTKQIKELTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSAAEKANLRKFTNAIKQVLHNEQ

Nucleotide

• Length: 339 bp

>T87056 NZ_CP024185:c1300119-1299781 [Moraxella osloensis]
TTGCACTTTATTGAAACACCTCTTTTTACCAAGCAAATCAAAGAACTGACAGACGATGATAATTATCGAGATTTGCAAGA
GGATTTAATAAAAAATCCCCAGCAAGGCGACCTAGTTCAAGGCACAGGCGGTGTTCGTAAAACTCGTTGGTCGTCATCAT
CTTCTACTGGTAAAAGCGGTGGTATGCGTATCATTTACTATTATATAGAGGAGTCGGGCAAGTTTTTTATGTTATTGGCT
TACCCAAAATCAAAAAAAGTCACACTATCTGCCGCAGAAAAAGCAAATTTGCGTAAATTCACAAACGCTATCAAACAGGT
ACTACACAATGAGCAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10336.81 Da
• Isoelectric Point: 7.0111

>AT87056 WP_036593973.1 NZ_CP024185:c1299791-1299510 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIAKGEAEPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELIALA

Nucleotide

• Length: 282 bp

>AT87056 NZ_CP024185:c1299791-1299510 [Moraxella osloensis]
ATGAGCAATGAATTTTATGATGATTTATCATTATCTCTTTCTCAAGCATTAAGCATTGCCAAAGGCGAAGCCGAGCCAAG
CCGTGTTTTTAGTTATGAGTTGCCAGATATTAAGGCAATCCGAGCTAAAACAGGACTAACACAGGCACAATTCGCCGATA
AGTTAAATATAAGTTCTCGCACGTTACAAAATTGGGAGCAAGGTACAAGACACCCTACAGGGGCAACGATTACGCTCATG
CGGCTTTTGGAAAAAAAGCCAGAACTGATTGCGTTAGCTTAA