Detailed information of TA system TA087054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1301591..1302200
• Replicon: chromosome
• Accession: NZ_CP024176
• Organism: Moraxella osloensis strain YHS

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: YHS_RS05775
• Protein ID: WP_198510535.1
• Coordinates: 1301862..1302200 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: YHS_RS05770
• Protein ID: WP_036593973.1
• Coordinates: 1301591..1301872 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YHS_RS05755	1298131..1299009	+	879	WP_099834001.1	RDD family protein	-
YHS_RS05760	1299060..1301276	+	2217	WP_099834002.1	FtsW/RodA/SpoVE family cell cycle protein	-
YHS_RS05765	1301286..1301534	+	249	WP_099834003.1	hypothetical protein	-
YHS_RS05770	1301591..1301872	-	282	WP_036593973.1	helix-turn-helix domain-containing protein	Antitoxin
YHS_RS05775	1301862..1302200	-	339	WP_198510535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YHS_RS05780	1302424..1305276	+	2853	WP_198510536.1	hypothetical protein	-
YHS_RS05785	1305302..1306897	+	1596	WP_099834006.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-77)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12820.60 Da
• Isoelectric Point: 9.8468

>T87054 WP_198510535.1 NZ_CP024176:c1302200-1301862 [Moraxella osloensis]
MHFIETPLFTKQIKELTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSAAEKANLRKFTNAIKQVLHNEQ

Nucleotide

• Length: 339 bp

>T87054 NZ_CP024176:c1302200-1301862 [Moraxella osloensis]
TTGCACTTTATTGAAACACCTCTTTTTACCAAGCAAATCAAAGAACTGACAGACGATGATAATTATCGAGATTTGCAAGA
GGATTTAATAAAAAATCCCCAGCAAGGCGACCTAGTTCAAGGCACAGGCGGTGTTCGTAAAACTCGTTGGTCGTCATCAT
CTTCTACTGGTAAAAGCGGTGGTATGCGTATCATTTACTATTATATAGAGGAGTCGGGCAAGTTTTTTATGTTATTGGCT
TACCCAAAATCAAAAAAAGTCACACTATCTGCCGCAGAAAAAGCAAATTTGCGTAAATTCACAAACGCTATCAAACAGGT
ACTACACAATGAGCAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10336.81 Da
• Isoelectric Point: 7.0111

>AT87054 WP_036593973.1 NZ_CP024176:c1301872-1301591 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIAKGEAEPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELIALA

Nucleotide

• Length: 282 bp

>AT87054 NZ_CP024176:c1301872-1301591 [Moraxella osloensis]
ATGAGCAATGAATTTTATGATGATTTATCATTATCTCTTTCTCAAGCATTAAGCATTGCCAAAGGCGAAGCCGAGCCAAG
CCGTGTTTTTAGTTATGAGTTGCCAGATATTAAGGCAATCCGAGCTAAAACAGGACTAACACAGGCACAATTCGCCGATA
AGTTAAATATAAGTTCTCGCACGTTACAAAATTGGGAGCAAGGTACAAGACACCCTACAGGGGCAACGATTACGCTCATG
CGGCTTTTGGAAAAAAAGCCAGAACTGATTGCGTTAGCTTAA